Li Yun-Feng, Wei Ya-Feng, Tian Jun, Zhang Juan, Chang Hong-Hong, Gao Wen-Chao
College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, People's Republic of China.
Shanxi Tihondan Pharmaceutical Technology Co. Ltd., Jinzhong 030600, People's Republic of China.
Org Lett. 2022 Aug 12;24(31):5736-5740. doi: 10.1021/acs.orglett.2c02160. Epub 2022 Jul 29.
Differentiation between similarly reactive sites in molecules represents an ongoing challenge of organic synthesis. Herein we described one kind of versatile reagents, -thiohydroxy succinimide esters (NTSEs), serving as both acyl and acylthio surrogates for the diverse synthesis of ketones, thioesters, amides, and acyl disulfides by selective cleavage of similarly reactive C-S and N-S bonds.
区分分子中类似的反应位点是有机合成中一个持续存在的挑战。在此，我们描述了一种多功能试剂，N-硫代羟基琥珀酰亚胺酯（NTSEs），它可作为酰基和酰硫代替代物，通过选择性裂解类似反应性的C-S和N-S键，用于酮、硫酯、酰胺和酰基二硫化物的多样合成。
