Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN, USA.
Ann Diagn Pathol. 2022 Oct;60:152014. doi: 10.1016/j.anndiagpath.2022.152014. Epub 2022 Jul 22.
Malignant rhabdoid tumor of the kidney (MRTK) is a rare aggressive pediatric renal tumor which can be diagnosed via fine-needle aspiration (FNA) cytology and core biopsy. The diagnosis of MRTK is challenging, and requires morphologic, immunohistochemical and clinical correlation to distinguish it from other entities. The differential diagnosis includes Wilms tumor, desmoplastic small round cell tumor, rhabdomyosarcoma, synovial sarcoma, renal medullary carcinoma, and epithelioid sarcoma. Here we describe a case of MRTK diagnosed on renal cytology and core biopsy with immunohistochemistry and follow by nephrectomy with gross and morphologic findings.
肾恶性横纹肌样瘤（MRTK）是一种罕见的侵袭性小儿肾肿瘤，可通过细针抽吸细胞学和核心活检进行诊断。MRTK 的诊断具有挑战性，需要形态学、免疫组织化学和临床相关性来将其与其他实体区分开来。鉴别诊断包括肾母细胞瘤、促结缔组织增生性小圆细胞肿瘤、横纹肌肉瘤、滑膜肉瘤、肾髓质癌和上皮样肉瘤。在这里，我们描述了一例通过肾细胞学和核心活检、免疫组织化学诊断的 MRTK 病例，并进行了肾切除术，观察大体和形态学发现。
