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经皮治疗系统:纳米纤维素影响甲基纤维素-壳聚糖生物纳米复合材料的研究。

Transdermal therapeutic system: Study of cellulose nanocrystals influenced methylcellulose-chitosan bionanocomposites.

机构信息

Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, West Bengal, India.

Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, West Bengal, India; Centre for Research in Nanoscience and Nanotechnology, Acharya Prafulla Chandra Roy Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Saltlake City, Kolkata 700098, India; School of Polymer Science and Engineering, University of Southern Mississippi, 118 College Drive #5050, Hattiesburg, MS 39406, United States of America.

出版信息

Int J Biol Macromol. 2022 Oct 1;218:556-567. doi: 10.1016/j.ijbiomac.2022.07.166. Epub 2022 Jul 26.

Abstract

Over the past few years, there is a drive toward the fabrication and application of bio-based non-cytotoxic drug carriers. Cellulose nanocrystals (CNCs) have gotten immense research attention as a promising bioderived material in the biomedical field due to its remarkable properties. The delivery of analgesic and anti-inflammatory drug, ketorolac tromethamine (KT) by transdermal route is stipulated herewith to fabricate suitable transdermal therapeutic systems. We have synthesized CNCs from jute fibers and aim to develop a non-cytotoxic polymer-based bionanocomposites (BNCs) transdermal patch, formulated with methylcellulose (MC), chitosan (CH), along with exploration of CNCs for sustained delivery of KT, where CNCs act as nanofiller and elegant nanocarrier. CNCs reinforced MCCH blends were prepared via the solvent evaporation technique. The chemical structure, morphology, and thermal stability of the prepared bionanocomposites formulations were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), TGA, DSC, DMA, and SEM. The In vitro drug release studies were executed using Franz diffusion cells. The BNC patches showed in-vitro cytocompatibility and the drug release study revealed that BNC containing 1 wt% CNCs presented the best-sustained drug release profile. The bioderived CNCs appear to enhance the BNCs drug's bioavailability, which could have a broad prospect for TDD applications.

摘要

在过去的几年中,人们一直在努力制造和应用基于生物的非细胞毒性药物载体。由于其显著的特性,纤维素纳米晶体(CNC)作为一种有前途的生物衍生材料,在生物医学领域引起了广泛的研究关注。本文旨在通过经皮途径输送镇痛和抗炎药物酮咯酸氨丁三醇(KT),以制备合适的经皮治疗系统。我们已经从黄麻纤维中合成了 CNC,并旨在开发一种基于非细胞毒性聚合物的生物纳米复合材料(BNC)经皮贴片,该贴片由甲基纤维素(MC)、壳聚糖(CH)组成,并探索 CNC 对 KT 的持续释放,其中 CNC 作为纳米填料和优雅的纳米载体。通过溶剂蒸发技术制备了 CNC 增强的 MCCH 共混物。通过傅里叶变换红外(FTIR)光谱、X 射线衍射(XRD)、TGA、DSC、DMA 和 SEM 研究了制备的生物纳米复合材料配方的化学结构、形态和热稳定性。通过 Franz 扩散细胞进行了体外药物释放研究。BNC 贴片表现出体外细胞相容性,药物释放研究表明,含有 1wt%CNC 的 BNC 呈现出最佳的持续药物释放曲线。生物衍生的 CNC 似乎可以提高 BNC 药物的生物利用度,这可能为 TDD 的应用提供广阔的前景。

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