Dobbs Katherine R, Dent Arlene E, Embury Paula, Ogolla Sidney, Koech Emmily, Midem David, Kazura James W
Centre for Global Health and Diseases, Case Western Reserve University, 10900 Euclid Avenue LC:4983, Cleveland, OH 44106, USA; Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA.
Centre for Global Health and Diseases, Case Western Reserve University, 10900 Euclid Avenue LC:4983, Cleveland, OH 44106, USA.
Int J Parasitol. 2022 Oct;52(11):717-720. doi: 10.1016/j.ijpara.2022.07.001. Epub 2022 Jul 26.
Children under the age of 5 years living in areas of moderate to high malaria transmission are highly susceptible to clinical malaria with fever that prompts treatment of blood stage infection with anti-malarial drugs. In contrast, older school age children frequently experience subclinical malaria, i.e. chronic Plasmodium falciparum parasitemia without fever or other clinical symptoms. The role of innate immune cells in regulating inflammation at a level that is sufficient to control the parasite biomass, while at the same time maintaining a disease-tolerant clinical phenotype, i.e., subclinical malaria, is not well understood. Recent studies suggest that host epigenetic mechanisms underlie the innate immune homeostasis associated with subclinical malaria. This Current Opinion article presents evidence supporting the notion that modifications of the host monocyte/macrophage epigenome regulate innate immune functions pertinent to subclinical malaria.
生活在疟疾中度至高度传播地区的5岁以下儿童极易感染伴有发热的临床疟疾，发热促使使用抗疟药物治疗血液阶段感染。相比之下，年龄较大的学龄儿童经常经历亚临床疟疾，即慢性恶性疟原虫血症，无发热或其他临床症状。先天免疫细胞在调节炎症水平以控制寄生虫数量，同时维持疾病耐受临床表型（即亚临床疟疾）方面的作用尚未完全明确。最近的研究表明，宿主表观遗传机制是亚临床疟疾相关先天免疫稳态的基础。这篇“当前观点”文章提供了证据支持宿主单核细胞/巨噬细胞表观基因组的修饰调节与亚临床疟疾相关的先天免疫功能这一观点。
