Rong Ze, Zheng Kaifeng, Chen Jun, Jin Xiaofeng
Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China.
Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China.
Gene. 2022 Oct 5;840:146772. doi: 10.1016/j.gene.2022.146772. Epub 2022 Jul 26.
The expression of ULK1, a core protein of autophagy, is closely related to autophagic activity. Numerous studies have shown that pathological abnormal expression of ULK1 is associated with various human diseases such as neurological disorders, infections, cardiovascular diseases, liver diseases and cancers. In addition, new advances in the regulation of ULK1 have been identified. Furthermore, targeting ULK1 as a therapeutic strategy for diseases is gaining attention as new corresponding activators or inhibitors are being developed. In this review, we describe the structure and regulation of ULK1 as well as the current targeted activators and inhibitors. Moreover, we highlight the pathological disorders of ULK1 expression and its critical role in human diseases.
自噬核心蛋白ULK1的表达与自噬活性密切相关。大量研究表明，ULK1的病理性异常表达与多种人类疾病相关，如神经紊乱、感染、心血管疾病、肝脏疾病和癌症。此外，已发现ULK1调控方面的新进展。而且，随着新型相应激活剂或抑制剂的研发，将ULK1作为疾病治疗策略正受到关注。在本综述中，我们描述了ULK1的结构与调控以及当前的靶向激活剂和抑制剂。此外，我们强调了ULK1表达的病理紊乱及其在人类疾病中的关键作用。
