Broz J, Frigg M
Vet Res Commun. 1987;11(2):159-72. doi: 10.1007/BF00344947.
Two growth experiments were conducted to evaluate in broiler chicks the compatibility between lasalocid medication in the feed (at 90 or 125 ppm) and a long-term administration of chloramphenicol either via the feed (500 ppm) or via the drinking water (500 mg/liter). The simultaneous administration of lasalocid and chloramphenicol generally caused severe growth depression, decreased feed intake and impaired feed conversion. Several chicks showed evident symptoms of intoxication, such as ataxia, leg weakness and paralysis. The development and frequency of these symptoms were dependent on the dosage of lasalocid and on the duration of the simultaneous administration. Biochemical examinations (Experiment 2) revealed in the affected chicks significant changes in several parameters, in particular a markedly increased activity of creatine kinase and GOT in the plasma. It confirmed that the observed leg weakness and paralysis were caused by myodegeneration.
进行了两项生长实验，以评估肉仔鸡饲料中添加拉沙洛西（90或125 ppm）与长期通过饲料（500 ppm）或饮用水（500毫克/升）给予氯霉素之间的兼容性。同时给予拉沙洛西和氯霉素通常会导致严重的生长抑制、采食量下降和饲料转化率受损。几只雏鸡出现明显的中毒症状，如共济失调、腿部无力和麻痹。这些症状的发展和出现频率取决于拉沙洛西的剂量和同时给药的持续时间。生化检查（实验2）显示，受影响的雏鸡多项参数有显著变化，特别是血浆中肌酸激酶和谷草转氨酶的活性明显增加。这证实了观察到的腿部无力和麻痹是由肌肉变性引起的。
