Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.
Pediatr Res. 2023 Mar;93(4):1017-1023. doi: 10.1038/s41390-022-02180-y. Epub 2022 Jul 29.
To investigate if an association exists between motion artefacts on brain MRI and comprehension, co-ordination, or hyperactivity scores in children aged 6-8 years, cooled for neonatal encephalopathy (cases) and controls.
Case children (n = 50) without cerebral palsy were matched with 43 controls for age, sex, and socioeconomic status. Children underwent T1-weighted (T1w), diffusion-weighted image (DWI) brain MRI and cognitive, behavioural, and motor skills assessment. Stepwise multivariable logistic regression assessed associations between unsuccessful MRI and comprehension (including Weschler Intelligence Scale for Children (WISC-IV) verbal comprehension, working memory, processing speed and full-scale IQ), co-ordination (including Movement Assessment Battery for Children (MABC-2) balance, manual dexterity, aiming and catching, and total scores) and hyperactivity (including Strengths and Difficulties Questionnaire (SDQ) hyperactivity and total difficulties scores).
Cases had lower odds of completing both T1w and DWIs (OR: 0.31, 95% CI 0.11-0.89). After adjusting for case-status and sex, lower MABC-2 balance score predicted unsuccessful T1w MRI (OR: 0.81, 95% CI 0.67-0.97, p = 0.022). Processing speed was negatively correlated with relative motion on DWI (r = -0.25, p = 0.026) and SDQ total difficulties score was lower for children with successful MRIs (p = 0.049).
Motion artefacts on brain MRI in early school-age children are related to the developmental profile.
Children who had moderate/severe neonatal encephalopathy are less likely to have successful MRI scans than matched controls. Motion artefact on MRI is associated with lower MABC-2 balance scores in both children who received therapeutic hypothermia for neonatal encephalopathy and matched controls, after controlling for case-status and sex. Exclusion of children with motion artefacts on brain MRI can introduce sampling bias, which impacts the utility of neuroimaging to understand the brain-behaviour relationship in children with functional impairments.
研究 6-8 岁患有新生儿脑病并接受冷却治疗的病例儿童和对照组儿童的脑 MRI 运动伪影与认知、协调或多动评分之间是否存在关联。
选择无脑瘫的病例儿童（n=50）与年龄、性别和社会经济地位相匹配的对照组儿童（n=43）进行 T1 加权（T1w）、弥散加权图像（DWI）脑 MRI 检查以及认知、行为和运动技能评估。逐步多变量逻辑回归评估不成功 MRI 与认知（包括韦氏儿童智力量表第四版（WISC-IV）的言语理解、工作记忆、加工速度和全量表智商）、协调（包括儿童运动评估量表（MABC-2）的平衡、手眼协调、瞄准和接球以及总分）和多动（包括长处和困难问卷（SDQ）的多动和总困难评分）之间的关联。
病例组完成 T1w 和 DWI 的可能性均较低（OR：0.31，95%CI 0.11-0.89）。在调整病例状态和性别后，MABC-2 平衡评分较低预示着 T1w MRI 不成功（OR：0.81，95%CI 0.67-0.97，p=0.022）。加工速度与 DWI 上的相对运动呈负相关（r=-0.25，p=0.026），SDQ 总困难评分在 MRI 成功的儿童中较低（p=0.049）。
在早期学龄儿童的脑 MRI 上出现运动伪影与发育状况有关。
与匹配的对照组相比，患有中重度新生儿脑病的儿童不太可能有成功的 MRI 扫描。在控制病例状态和性别后，接受新生儿脑病治疗性低温的儿童和匹配对照组的儿童，MRI 上的运动伪影与 MABC-2 平衡评分较低相关。在脑 MRI 上存在运动伪影的儿童被排除在外可能会引入抽样偏差，从而影响神经影像学在理解有功能障碍的儿童的大脑-行为关系中的应用。
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