Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Eur J Clin Nutr. 2022 Dec;76(12):1713-1718. doi: 10.1038/s41430-022-01186-3. Epub 2022 Jul 29.
The aim of the present study was to assess the efficacy of feeding a higher-density formula (HDF) in infant with congenital heart disease (CHD).
In a parallel randomized trial, infants (6 to 12 months) who underwent CHD corrective surgery received either a standard-density formula (SDF, 67 kcal /100 ml) or an HDF (90 kcal/100 ml) after discharge from the intensive care unit for 8 weeks. In addition to the formula, infants could receive breast milk or complementary food. Anthropometry, biochemistry, and formula intake were collected.
Sixty-four infants completed the study (n = 32 in each group). All infants gained weight. The mean ± standard deviation (SD) of weight z score at baseline and week-8 were -2.38 ± 10.04 to -1.38 + 0.97 in the SDF group and -2.69 ± 1.19 to -0.89 ± 0.90 in the HDF group (between-group p = 0.0001). Both groups gained length, but showed a decline in length z-score which was significant in the SDF group but not significant in the HDF group. Mid-upper arm circumference and its z score improved in both groups, with more improvement in the HDF group. Serum albumin level was higher in the HDF than the SDF group at week-8, but no significant between-group differences were observed in hemoglobin, serum ferritin, or iron. Symptoms of gastrointestinal intolerance were not reported, but parents of 4 infants in the HDF group complained of their infants' constipation.
Feeding infants using a concentrated formula could increase infants' weight gain and growth, and improve the nutritional status after CHD surgery.
本研究旨在评估喂养高密度配方（HDF）对先天性心脏病（CHD）婴儿的疗效。
在一项平行随机试验中，接受 CHD 矫正手术后的婴儿（6-12 个月）在重症监护病房出院后 8 周内接受标准密度配方（SDF，67kcal/100ml）或 HDF（90kcal/100ml）。除配方外，婴儿还可以接受母乳或补充食物。收集人体测量学、生物化学和配方摄入量数据。
64 名婴儿完成了研究（每组 n=32）。所有婴儿均体重增加。SDF 组和 HDF 组的体重 z 评分在基线和第 8 周的平均值±标准差（SD）分别为-2.38±10.04 至-1.38+0.97 和-2.69±1.19 至-0.89±0.90（组间 p=0.0001）。两组均增加了身长，但身长 z 评分下降，SDF 组显著下降，HDF 组则不显著。两组的上臂中部周长及其 z 评分均有所改善，HDF 组的改善更为明显。HDF 组血清白蛋白水平在第 8 周时高于 SDF 组，但血红蛋白、血清铁蛋白或铁水平在两组间无显著差异。未报告胃肠道不耐受症状，但 HDF 组有 4 名婴儿的家长抱怨其婴儿便秘。
喂养浓缩配方可增加婴儿的体重增加和生长，并改善 CHD 手术后的营养状况。
