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体外机械循环支持系统的液力悬浮离心血泵泄漏流量的数值模拟。

Numerical simulation of the leakage flow of the hydrodynamically levitated centrifugal blood pump for extracorporeal mechanical circulatory support systems.

机构信息

Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 6-1 Kishibe-Shinmachi, Suita, Osaka, 5648565, Japan.

出版信息

J Artif Organs. 2023 Sep;26(3):176-183. doi: 10.1007/s10047-022-01351-2. Epub 2022 Jul 30.

DOI:10.1007/s10047-022-01351-2
PMID:35907152
Abstract

Extracorporeal centrifugal pumps are widely used in various forms of mechanical circulatory support, including extracorporeal membrane oxygenation and ventricular assist device. A durable centrifugal pump was developed by implementing a new hydrodynamic bearing design that prevents the impeller from touching to the casing wall and provides sufficient washout through the pump to prevent thrombus formation in the pump. The hydrodynamic bearings of the pump are composed of dual annular paths located on both sides of the impeller. Computational fluid dynamics analyses were performed on the flow field inside the pump to estimate the leakage flow through the gap and its impact on the pump efficiency and biocompatibility. The calculations were performed for motor speeds from 3000 to 5000 rpm and flow rates from 1.0 to 9.0 L/min. The leakage flow increased linearly with increasing pressure head of the pump, and the total leakage flow ranged from 2.0 to 27.3% of the total flow. The average wall shear stresses in the casing bottom ranged from 10.6 to 40.9 Pa. The leakage flow of the centrifugal pump with the hydrodynamically levitated impeller had a measurable impact on hydraulic energy losses while enhancing the washout flow to achieve good anti-thrombogenicity.

摘要

体外离心泵广泛应用于各种形式的机械循环支持,包括体外膜氧合和心室辅助装置。通过实施一种新的液动轴承设计,开发了一种耐用的离心泵,该设计可防止叶轮接触机壳壁,并通过泵提供足够的冲洗,以防止泵内血栓形成。泵的液动轴承由位于叶轮两侧的双环形通道组成。对泵内流场进行了计算流体动力学分析,以估算通过间隙的泄漏流量及其对泵效率和生物相容性的影响。计算是在电机转速为 3000 至 5000rpm 和流量为 1.0 至 9.0L/min 的情况下进行的。泄漏流量随泵的扬程线性增加,总泄漏流量占总流量的 2.0%至 27.3%。机壳底部的平均壁面剪切应力范围为 10.6 至 40.9Pa。具有液力悬浮叶轮的离心泵的泄漏流量对水力能量损失有一定的影响,同时增强了冲洗流量,以实现良好的抗血栓形成性能。

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本文引用的文献

1
A Novel Extracorporeal Continuous-Flow Ventricular Assist System for Patients With Advanced Heart Failure - Initial Clinical Experience.一种新型体外连续流心室辅助系统治疗晚期心力衰竭患者的初步临床经验。
Circ J. 2020 Jun 25;84(7):1090-1096. doi: 10.1253/circj.CJ-19-1122. Epub 2020 May 28.
2
Miniaturized centrifugal ventricular assist device for bridge to decision: Preclinical chronic study in a bovine model.用于桥接决策的微型离心心室辅助装置:牛模型中的临床前慢性研究。
Artif Organs. 2019 Sep;43(9):821-827. doi: 10.1111/aor.13459. Epub 2019 Apr 25.
3
Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure.
磁悬浮离心泵治疗心力衰竭的两年结果。
N Engl J Med. 2018 Apr 12;378(15):1386-1395. doi: 10.1056/NEJMoa1800866. Epub 2018 Mar 11.
4
Novel temporary left ventricular assist system with hydrodynamically levitated bearing pump for bridge to decision: initial preclinical assessment in a goat model.用于桥接决策的新型带流体动力学悬浮轴承泵的临时左心室辅助系统:山羊模型的初步临床前评估
J Artif Organs. 2018 Mar;21(1):23-30. doi: 10.1007/s10047-017-0989-y. Epub 2017 Sep 12.
5
Preclinical study of a novel hydrodynamically levitated centrifugal pump for long-term cardiopulmonary support : In vivo performance during percutaneous cardiopulmonary support.一种用于长期心肺支持的新型流体动力学悬浮离心泵的临床前研究:经皮心肺支持期间的体内性能
J Artif Organs. 2015 Dec;18(4):300-6. doi: 10.1007/s10047-015-0842-0. Epub 2015 May 15.
6
Unexpected abrupt increase in left ventricular assist device thrombosis.左心室辅助装置血栓形成的意外急剧增加。
N Engl J Med. 2014 Jan 2;370(1):33-40. doi: 10.1056/NEJMoa1313385. Epub 2013 Nov 27.
7
Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation.经心室内连续流离心式血泵在等待心脏移植患者中的应用。
Circulation. 2012 Jun 26;125(25):3191-200. doi: 10.1161/CIRCULATIONAHA.111.058412. Epub 2012 May 22.
8
Left heart bypass support with the Rotaflow Centrifugal Pump® as a bridge to decision and recovery in an adult.使用Rotaflow离心泵®进行左心旁路支持作为成人决策和康复的桥梁。
J Artif Organs. 2012 Jun;15(2):207-10. doi: 10.1007/s10047-012-0632-x. Epub 2012 Feb 23.
9
Evolution of the extracorporeal life support circuitry.体外生命支持回路的演变。
Artif Organs. 2010 Nov;34(11):869-73. doi: 10.1111/j.1525-1594.2010.01127.x.
10
In vitro and computational thrombosis on artificial surfaces with shear stress.体外和计算血栓形成在具有剪切应力的人工表面上。
Artif Organs. 2010 Jul;34(7):561-9. doi: 10.1111/j.1525-1594.2009.00930.x. Epub 2010 May 21.