Maleev A, Naumov N
Vutr Boles. 1987;26(1):14-8.
The continuous application of colchicine reduces considerably the incidence of the paroxysms in patients with periodic disease. A patient is described, a Bulgarian, with periodic disease with a duration of 40 years (family Mediterranean fever), successfully treated with intermittent application of colchicine according to a schedule for the last 3 years. The evolution of the clinical manifestations was followed up as well as the absence of effect by the corticosteroid therapy applied before. The intermittent application of colchicine, in this case, prevents totally the paroxysms with high temperature and pain in abdomen, chest and joints with a considerable smaller amount of the drug applied. The intermittent application of colchicine should first be tried in the treatment of patients with periodic diseases.
持续应用秋水仙碱可显著降低周期性疾病患者发作的发生率。本文描述了一名保加利亚患者，患有长达40年的周期性疾病（家族性地中海热），在过去3年中按照时间表间歇性应用秋水仙碱成功治愈。随访了临床表现的演变以及之前应用皮质类固醇治疗无效的情况。在这种情况下，间歇性应用秋水仙碱能以相当少量的药物完全预防高热以及腹部、胸部和关节疼痛的发作。在周期性疾病患者的治疗中应首先尝试间歇性应用秋水仙碱。
