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[高脂血症患者中降血脂药物的适应证及治疗作用]

[Indications for and the therapeutic action of hypolipidemic agents in patients with hyperlipoproteinemias].

作者信息

Goranov I, Naumova R, Kerekovska M, Balabanski L

出版信息

Vutr Boles. 1987;26(1):96-101.

PMID:3590738
Abstract

Seventy three patients with hyperlipoproteinemia (HLP) type II and IV were divided into three groups and treated with different pharmaceuticals. The first group was treated with 300 mg Radecol daily, the second--with 750 mg Probucol and the third--with 600 mg Bezalip. Best results in the patients with HLP, type II A, as regards the effect on total cholesterol were obtained in those treated with Probucol, in type II B the results from the treatment with Radecol and Probucol are similar. In type IV HLP the reduction of triglycerides is best manifested in those treated with Bezalip. The tolerance and indications for the treatment of the patients with the three preparations are evaluated with a view to individualization of the medicamentous treatment.

摘要

73例II型和IV型高脂蛋白血症(HLP)患者被分为三组,接受不同药物治疗。第一组每天服用300毫克雷得可,第二组服用750毫克丙丁酚,第三组服用600毫克必降脂。就对总胆固醇的影响而言,II A型HLP患者使用丙丁酚治疗效果最佳,II B型中雷得可和丙丁酚治疗效果相似。在IV型HLP中,必降脂治疗的患者甘油三酯降低最为明显。对这三种制剂治疗患者的耐受性和适应证进行了评估,以期实现药物治疗的个体化。

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