Department of Family Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Department of Family Medicine, Korea University College of Medicine, Seoul, South Korea.
Diabetes Res Clin Pract. 2022 Aug;190:110015. doi: 10.1016/j.diabres.2022.110015. Epub 2022 Jul 28.
This study aimed to examine the association between body weight variability and dementia risk using a large-scale cohort data of Korean patients with type 2 diabetes mellitus (T2DM).
A population-based cohort of 1,206,764 individuals with T2DM aged ≥ 40 years who underwent ≥ 3 Korean national health screenings were followed up until the end of 2019. Body weight variability was assessed using variability independent of the mean (VIM). A multivariate Cox proportional hazard regression was performed with calculating hazard ratios (HRs) with 95 % confidence intervals (CIs) of dementia incidence.
During a median follow-up of 7.9 years, 162,615 (13.4 %) individuals developed dementia. Individuals with greater body weight variability tended to be associated with higher risk of all types of dementia (P for trend < 0.001). Individuals in the highest quartile of VIM showed 26 % (HR: 1.26, 95 % CI: 1.24-1.28), 33 % (HR: 1.33, 95 % CI: 1.30-1.36) and 28 % (HR: 1.28, 95 % CI: 1.23-1.33) higher risk for all-cause dementia, Alzheimer's disease, and vascular dementia, compared with those in the lowest quartile. These associations persisted in all body mass index categories (P for trend < 0.001).
Maintaining an appropriate body weight may help mitigate dementia risk in patients with T2DM.
本研究旨在利用韩国 2 型糖尿病（T2DM）患者的大规模队列数据，研究体重变异性与痴呆风险之间的关系。
本研究纳入了年龄≥40 岁且接受了≥3 次韩国国家健康筛查的 1206764 例 T2DM 患者，对其进行了基于人群的队列研究。使用均值无关的变异性（VIM）评估体重变异性。使用多变量 Cox 比例风险回归计算痴呆发生率的风险比（HR）及其 95%置信区间（CI）。
在中位随访 7.9 年期间，162615 例（13.4%）患者发生了痴呆。体重变异性较大的个体发生各种类型痴呆的风险更高（趋势 P<0.001）。VIM 最高四分位数的个体发生全因痴呆、阿尔茨海默病和血管性痴呆的风险分别增加 26%（HR：1.26，95%CI：1.24-1.28）、33%（HR：1.33，95%CI：1.30-1.36）和 28%（HR：1.28，95%CI：1.23-1.33），与 VIM 最低四分位数的个体相比。这些关联在所有 BMI 类别中均持续存在（趋势 P<0.001）。
维持适当的体重可能有助于降低 T2DM 患者的痴呆风险。
