International Center for Wound Repair and Regeneration, National Cheng-Kung University, Tainan, Taiwan.
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
J Control Release. 2022 Sep;349:765-782. doi: 10.1016/j.jconrel.2022.07.031. Epub 2022 Aug 2.
Long considered as no more than biological waste meant to be eliminated in urine, glucuronides have recently contributed to tremendous developments in the biomedical field, particularly against cancer. While glucuronide prodrugs monotherapy and antibody-directed enzyme prodrug therapy have been around for some time, new facets have emerged that combine the unique properties of glucuronides notably in the fields of antibody-drug conjugates and nanomedicine. In both cases, glucuronides are utilized as a vector to improve pharmacokinetics and confer localized activation of potent drugs at tumor sites while also decreasing systemic toxicity. Here we will discuss some of the most promising strategies using glucuronides to promote successful anti-tumor therapeutic treatments.
长期以来，人们一直认为葡萄糖醛酸苷不过是生物废物，应该随尿液排出体外，但最近它在生物医药领域取得了巨大的发展，尤其是在抗癌方面。尽管葡萄糖醛酸苷前药单药治疗和抗体导向酶前药疗法已经存在了一段时间，但新的方面已经出现，将葡萄糖醛酸苷的独特性质结合起来，特别是在抗体药物偶联物和纳米医学领域。在这两种情况下，葡萄糖醛酸苷都被用作载体，以改善药代动力学，并在肿瘤部位局部激活有效的药物，同时降低全身毒性。在这里，我们将讨论一些使用葡萄糖醛酸苷来促进成功的抗肿瘤治疗的最有前途的策略。
