从红树林内生真菌米曲霉中分离得到的 4 种新的二苯醚衍生物。

Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum.

机构信息

Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.

出版信息

Chin J Nat Med. 2022 Jul;20(7):537-540. doi: 10.1016/S1875-5364(22)60171-7.

DOI:10.1016/S1875-5364(22)60171-7

PMID:35907652

Abstract

Four new diphenyl ethers, named epicoccethers K-N (1-4), were purified from the fermentation medium of a fungus Epicoccum sorghinum derived from Myoporum bontioides, and identified through HR-ESI-MS and NMR spectral analysis. Except that compound 1 showed moderate antifungal activity against Penicillium italicum and Fusarium graminearum, the other three compounds showed stronger activity against them than triadimefon. All of them showed moderate or weak antibacterial activity towards Staphylococcus aureus and Escherichia coli with O6 and O78 serotypes except that 3 was inactive to E. coli O6.

摘要

四种新的二苯醚类化合物，命名为 epicoccethers K-N（1-4），从来源于 Myoporum bontioides 的真菌 Epicoccum sorghinum 的发酵培养基中分离出来，并通过高分辨电喷雾质谱（HR-ESI-MS）和核磁共振波谱（NMR）分析鉴定。除了化合物 1 对青霉菌和禾谷镰刀菌显示出中等的抗真菌活性外，其他三种化合物对它们的活性均强于三唑酮。除了 3 对大肠杆菌 O6 没有活性外，所有化合物对 O6 和 O78 血清型的金黄色葡萄球菌和大肠杆菌都显示出中等或弱的抗菌活性。