Erzincan Binali Yildirim University Faculty of Medicine, Department of Urology, Turkey.
Erzincan Binali Yildirim University Faculty of Medicine, Department of Urology, Turkey.
Rev Int Androl. 2022 Oct-Dec;20(4):225-230. doi: 10.1016/j.androl.2021.02.008. Epub 2022 Jul 27.
To evaluate nitric oxide (NO) and asymmetric dimethylarginine (ADMA) levels in men with premature ejaculation (PE), which is a common condition that adversely affects quality of life.
Of the 20-50-year old men presenting to the urology clinic, who were married or had regular sexual intercourse, 40 that were diagnosed with lifelong PE according to the Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT) measured by a stopwatch were included in the study. The results of the PE group were compared to those of the control group formed with 40 healthy hospital personnel. Venous blood samples were centrifuged and stored at -80°C. The NO and ADMA values were compared between the individuals with and without PE.
There was no statistically significant difference between the groups in terms of age, body mass index (BMI), and The International Erectile Dysfunction Index-5 (IIEF-5) questionnaire scores. The NO and ADMA values were significantly lower in the PE group than in the control group (29.76±13.26μmol/L vs. 48.27±22.71μmol/L; p<0.001 and 1.01±0.49nmol/ml vs. 1.83±1.06nmol/ml; p<0.001, respectively). There was a significant correlation between IELT and NO levels (r=0.407, p=0.001).
Our study can contribute to the explanation of the pathophysiology of PE having unclear etiology and treatment. Further studies on these molecules with larger case series are required for the diagnosis and treatment of PE.
评估早泄（PE）男性的一氧化氮（NO）和不对称二甲基精氨酸（ADMA）水平，PE 是一种常见的疾病，会对生活质量产生不利影响。
在泌尿科诊所就诊的 20-50 岁已婚或有规律性生活的男性中，根据早泄诊断工具（PEDT）和秒表测量的阴道内射精潜伏期时间（IELT）诊断为终身性 PE 的 40 例患者被纳入研究。将 PE 组的结果与由 40 名健康医院工作人员组成的对照组进行比较。采集静脉血样并在-80°C 下离心储存。比较有和无 PE 的个体之间的 NO 和 ADMA 值。
两组在年龄、体重指数（BMI）和国际勃起功能指数-5（IIEF-5）问卷评分方面无统计学差异。PE 组的 NO 和 ADMA 值明显低于对照组（29.76±13.26μmol/L 比 48.27±22.71μmol/L；p<0.001 和 1.01±0.49nmol/ml 比 1.83±1.06nmol/ml；p<0.001）。IELT 与 NO 水平之间存在显著相关性（r=0.407，p=0.001）。
本研究有助于解释病因和治疗方法尚不清楚的 PE 的病理生理学。需要进一步研究这些分子，以增加病例系列，为 PE 的诊断和治疗提供依据。
