The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, Hubei, China.
Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
Stem Cell Res Ther. 2022 Jul 30;13(1):383. doi: 10.1186/s13287-022-03059-9.
OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression.
OCT4 是一种主要的转录因子，可维持干细胞的多能性，包括胚胎干细胞、诱导多能干细胞和癌症干细胞。越来越多的长链非编码 RNA 被报道通过各种机制参与 OCT4 表达的调控，包括与 OCT4 基因启动子结合，调节局部甲基化；促进染色体空间折叠形成内环，从而聚集 OCT4 顺式作用元件，这些元件分散在染色体的不连续位点；竞争性地与 microRNAs 结合，在上转录后水平上调 OCT4 表达；并与 OCT4 共享启动子。此外，一些长链非编码 RNA 的转录受 OCT4 调节，某些长链非编码 RNA 与 OCT4 形成反馈调节环。在这篇综述中，我们总结了长链非编码 RNA 参与 OCT4 表达调控的研究进展。
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