Isik Puren, Harbiyeli Ibrahim Inan, Ozturk Gokhan, Erdem Elif, Yagmur Meltem, Yarkin Fugen
Ophthalmology Department, Faculty of Medicine, Balcali Hospital, Cukurova University, Turkey.
Virology Department, Faculty of Medicine, Cukurova University, Turkey.
Jpn J Infect Dis. 2022 Nov 22;75(6):592-596. doi: 10.7883/yoken.JJID.2022.210. Epub 2022 Jul 29.
The aim of this study was to evaluate the relationship between clinical findings and viral load in adenoviral keratoconjunctivitis (Ad-Kc). In this cross-sectional study, 30 eyes of 30 patients with Ad-Kc were assessed. Real-time polymerase chain reaction was performed to detect and quantify adenovirus in all samples. Patients were divided into three subgroups according to baseline viral load (<10, 10-10, >10 human adenovirus [HAdV] copies/mL). The duration of follow-up, HAdV DNA copy number, treatment regimen, and detailed clinical findings, including uncorrected visual acuity, eyelid edema, conjunctival hyperemia, chemosis, follicular reaction, corneal involvement, conjunctival pseudomembrane, and subepithelial infiltrates (SEIs) were recorded. This study showed that a high initial viral load was associated with the development of SEIs and pseudomembrane formation (P < 0.05). The clinical findings and ocular complications of Ad-Kc were similar in the treatment groups at the final examination (P > 0.05). Our results show that a high initial viral load in Ad-Kc may be predictive of inflammatory sequelae. Determining the initial viral load in Ad-Kc may help understand the clinical course of the disease better and prevent complications.
本研究旨在评估腺病毒性角结膜炎（Ad-Kc）的临床发现与病毒载量之间的关系。在这项横断面研究中，对30例Ad-Kc患者的30只眼睛进行了评估。采用实时聚合酶链反应对所有样本中的腺病毒进行检测和定量。根据基线病毒载量（<10、10 - 10、>10人腺病毒[HAdV]拷贝/毫升）将患者分为三个亚组。记录随访时间、HAdV DNA拷贝数、治疗方案以及详细的临床发现，包括未矫正视力、眼睑水肿、结膜充血、结膜水肿、滤泡反应、角膜受累、结膜假膜和上皮下浸润（SEIs）。本研究表明，初始病毒载量高与SEIs的发生和假膜形成相关（P < 0.05）。在最终检查时，各治疗组的Ad-Kc临床发现和眼部并发症相似（P > 0.05）。我们的结果表明，Ad-Kc中初始病毒载量高可能预示着炎症后遗症。确定Ad-Kc中的初始病毒载量可能有助于更好地了解疾病的临床过程并预防并发症。
