Inami Show, Sato Tomohito, Sakai Takaomi
Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA, United States.
Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Front Mol Neurosci. 2022 Jul 13;15:934222. doi: 10.3389/fnmol.2022.934222. eCollection 2022.
The neuropeptide pigment-dispersing factor (Pdf) is critically involved in the regulation of circadian rhythms in various insects. The function of Pdf in circadian rhythms has been best studied in the fruitfly, i.e., . Pdf is produced in a small subset of circadian clock neurons in the adult brain and functions as a circadian output signal. Recently, however, Pdf has been shown to play important roles not only in regulating circadian rhythms but also in innate and learned behaviors in . In this mini-review, we will focus on the current findings that Pdf signaling and Pdf-producing neurons are essential for consolidating and maintaining long-term memory induced by the courtship conditioning in and discuss the mechanisms of courtship memory processing through Pdf-producing neurons.
神经肽色素分散因子（Pdf）在多种昆虫的昼夜节律调节中起着关键作用。Pdf在昼夜节律中的功能在果蝇中得到了最深入的研究。Pdf由成年果蝇大脑中一小部分生物钟神经元产生，并作为昼夜节律输出信号发挥作用。然而，最近研究表明，Pdf不仅在调节昼夜节律方面发挥重要作用，而且在果蝇的先天行为和学习行为中也发挥重要作用。在这篇小型综述中，我们将聚焦于当前的研究发现，即Pdf信号传导和产生Pdf的神经元对于巩固和维持求偶条件反射诱导的长期记忆至关重要，并讨论通过产生Pdf的神经元进行求偶记忆处理的机制。
