精子 DNA 碎片对受精-胚胎移植（IVF-ET）临床结局的影响。
Influence of sperm DNA fragmentation on the clinical outcome of fertilization-embryo transfer (IVF-ET).
机构信息
Department of Reproductive Medicine Center, Clinical Medical College, Yangzhou University, Yangzhou, China.
Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Jul 14;13:945242. doi: 10.3389/fendo.2022.945242. eCollection 2022.
PURPOSE
To evaluate the effect of elevated sperm DNA fragmentation index (DFI) on fresh and frozen embryo transfer cycles.
METHODS
A retrospective study was performed with 549 fresh embryo transfer cycles and 1340 frozen embryo transfer cycles after fertilization/intracytoplasmic sperm injection (IVF/ICSI) from 2016 to 2021.
RESULTS
The statistical results of 549 fresh embryo transfer cycles showed that the delivery rate in the normal sperm DFI group (43.9% vs. 27.1%, = 0.014) was significantly higher than that in the abnormal sperm DFI group, and there were no significant differences in the biochemical pregnancy rate (59.0% vs. 50.8%, = 0.232), clinical pregnancy rate (53.1% vs. 40.7%, = 0.072), or miscarriage rate (17.3% vs. 33.3%, = 0.098) between the two groups. The results of 1340 frozen embryo transfer cycles showed that the biochemical pregnancy rate (57.9% vs. 45.6%, = 0.006) and clinical pregnancy rate (50.3% vs. 40.7%, = 0.027) in the normal sperm DFI group were significantly higher than those in the abnormal sperm DFI group. The delivery rate (40.9% vs. 33.3%, = 0.074) and miscarriage rate (18.6% vs. 18.0%, = 0.919) were not significantly different between the two groups.
CONCLUSION
The increase of sperm DFI significantly reduced the delivery rate of fresh embryo transfer cycles and the biochemical pregnancy rate and clinical pregnancy rate of frozen embryo transfer cycles.
目的
评估精子 DNA 碎片化指数（DFI）升高对新鲜胚胎移植和冷冻胚胎移植周期的影响。
方法
回顾性分析 2016 年至 2021 年间受精/卵胞浆内单精子注射（IVF/ICSI）后 549 个新鲜胚胎移植周期和 1340 个冷冻胚胎移植周期的数据。
结果
549 个新鲜胚胎移植周期的统计结果显示，正常精子 DFI 组的活产率（43.9%比 27.1%， = 0.014）明显高于异常精子 DFI 组，两组的生化妊娠率（59.0%比 50.8%， = 0.232）、临床妊娠率（53.1%比 40.7%， = 0.072）和流产率（17.3%比 33.3%， = 0.098）均无统计学差异。1340 个冷冻胚胎移植周期的结果显示，正常精子 DFI 组的生化妊娠率（57.9%比 45.6%， = 0.006）和临床妊娠率（50.3%比 40.7%， = 0.027）明显高于异常精子 DFI 组，而活产率（40.9%比 33.3%， = 0.074）和流产率（18.6%比 18.0%， = 0.919）无统计学差异。
结论
精子 DFI 的升高显著降低了新鲜胚胎移植周期的活产率以及冷冻胚胎移植周期的生化妊娠率和临床妊娠率。
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