Murray Christopher S G, Zamora Cristian, Shitole Sanyog G, Christa Panagiota, Lee Un Jung, Bortnick Anna E, Kizer Jorge R, Rodriguez Carlos J
Division of Cardiology, Montefiore Hospital, Bronx, NY.
Department of Medicine/Cardiology, Albert Einstein College of Medicine, Bronx, NY.
Ethn Dis. 2022 Jul 21;32(3):193-202. doi: 10.18865/ed.32.3.193. eCollection 2022 Summer.
Race and ethnicity are major considerations in the incidence, management, and long-term outcome of ST-elevation myocardial infarction (STEMI) in the United States, but there is limited existing comparative data.
We assembled a registry in a health system serving Bronx, NY of STEMI patients from 2008-2014 and analyzed differences in presentation, treatment and mortality between Hispanic/Latino (H/L), non-Hispanic Black (NHB) and non-Hispanic White (NHW). Upon discharge post-treatment for STEMI, all patients were followed for a median of 4.4 years (interquartile range 2.5, 6.0). Out of 966 STEMI patients, mean age was 61 years, 46% were H/L and 65% were male. H/Ls and NHBs had a higher prevalence of hypertension and diabetes mellitus than their NHW counterparts, coinciding with a lower socioeconomic status (SES).
The number of critically diseased vessels found at cardiac catheterization and mean troponin levels did not vary by race-ethnicity; neither did the adjusted hazard ratios (HR) for death. However, age-sex adjusted rates of general hospital readmission were higher in NHBs vs NHWs (HR 1.30, P=.03). Age-sex adjusted cardiovascular readmissions rates were higher in H/Ls than NHWs (HR 1.42, P=.03). Age-sex adjusted heart failure readmissions were increased for both H/Ls (HR 2.14, P=.01) and NHBs (HR 2.12, P=.02) over NHWs.
Among STEMI patients, a higher prevalence of modifiable cardiovascular risk factors and a lower SES was seen among NHBs and H/Ls compared to NHWs. Despite similar coronary disease severity and in-hospital death, NHBs and H/Ls had a greater risk of general, cardiovascular and heart failure readmissions post-STEMI compared to NHWs.
在美国,种族和族裔是ST段抬高型心肌梗死(STEMI)发病率、治疗及长期预后的主要考量因素,但现有比较数据有限。
我们在纽约布朗克斯区的一个医疗系统中建立了一个STEMI患者登记处,纳入了2008年至2014年的患者,并分析了西班牙裔/拉丁裔(H/L)、非西班牙裔黑人(NHB)和非西班牙裔白人(NHW)在临床表现、治疗和死亡率方面的差异。STEMI治疗出院后,对所有患者进行了中位时间为4.4年(四分位间距2.5,6.0)的随访。在966例STEMI患者中,平均年龄为61岁,46%为H/L,65%为男性。与NHW相比,H/L和NHB的高血压和糖尿病患病率更高,且社会经济地位(SES)较低。
心导管检查发现的严重病变血管数量和肌钙蛋白平均水平在不同种族-族裔间无差异;死亡的校正风险比(HR)也无差异。然而,NHB的年龄-性别校正后的综合医院再入院率高于NHW(HR 1.30,P = 0.03)。H/L的年龄-性别校正后的心血管再入院率高于NHW(HR 1.42,P = 0.03)。与NHW相比,H/L(HR 2.14,P = 0.01)和NHB(HR 2.12,P = 0.02)的年龄-性别校正后的心力衰竭再入院率均升高。
在STEMI患者中,与NHW相比,NHB和H/L中可改变的心血管危险因素患病率更高,SES更低。尽管冠心病严重程度和院内死亡率相似,但与NHW相比,NHB和H/L在STEMI后综合、心血管和心力衰竭再入院的风险更大。