Chao Meie, Genina Natalja, Beer Netta, Kälvemark Sporrong Sofia
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden.
Explor Res Clin Soc Pharm. 2022 Apr 22;6:100141. doi: 10.1016/j.rcsop.2022.100141. eCollection 2022 Jun.
In the field of pharmaceuticals, there is a shift away from the traditional "one-size-fits-all" concept to a more patient-centered one. A potential approach to obtain personalized medicine is with printed Data-Enriched Edible Pharmaceuticals (DEEPs). DEEPs that are printed in the pattern of QR codes contain both the patient-tailored dose and data that can be used to give patients personalized drug information and combat counterfeit medicines.
The study aims to explore patients' preferences, perceptions, and acceptability of DEEPs, and the digital aspects of them.
Thirteen participants, living in Denmark, were interviewed twice using a semi-structured approach. Interviews were conducted face-to-face or via video calls. The interviews were transcribed, translated, and analyzed using thematic coding analysis.
The participants found it useful to participate in the design of their own medicine. The orodispersible nature of DEEPs and the possibility to select color, embedded images, flavors, and physical dimensions of DEEPs were considered beneficial for patients' adherence. Patients' personal preferences, convenience, and aesthetics were the main drivers for their favored design of DEEPs. The acceptability of digital healthcare in connection to DEEPs was found to be related to the participants' level of digital literacy.
The participants generally had a positive attitude towards DEEPs and the digital aspects of them. However, to accept digital healthcare in connection to DEEPs, it should be adaptable and easy to use for everyone. The combination of digital healthcare and on-demand fabricated DEEPs could potentially contribute to higher patient adherence and safety in the future.
在制药领域，正从传统的“一刀切”概念转向更以患者为中心的理念。一种获得个性化药物的潜在方法是使用打印的富含数据的可食用药物（DEEPs）。以二维码形式打印的DEEPs既包含为患者量身定制的剂量，又包含可用于为患者提供个性化药物信息和打击假药的数据。
本研究旨在探索患者对DEEPs的偏好、认知和可接受性，以及它们的数字方面。
对居住在丹麦的13名参与者采用半结构化方法进行了两次访谈。访谈通过面对面或视频通话进行。访谈内容被转录、翻译并使用主题编码分析进行分析。
参与者发现参与自己药物的设计很有用。DEEPs的口腔崩解性质以及选择DEEPs的颜色、嵌入图像、口味和物理尺寸的可能性被认为有利于患者的依从性。患者的个人偏好、便利性和美观性是他们青睐的DEEPs设计的主要驱动因素。发现与DEEPs相关的数字医疗保健的可接受性与参与者的数字素养水平有关。
参与者总体上对DEEPs及其数字方面持积极态度。然而，要接受与DEEPs相关的数字医疗保健，它应该对每个人来说都是适应性强且易于使用的。数字医疗保健与按需制造的DEEPs的结合可能在未来有助于提高患者的依从性和安全性。
