Zeng Dechuang, Tang Xiqiang, Nong Feng, Yi Jinyuan, Yao Yuanxi, Luo Shiguan
Department of Cardiothoracic Vascular Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities of Baise, Guangxi 533000, China.
J Oncol. 2022 Jul 19;2022:8967162. doi: 10.1155/2022/8967162. eCollection 2022.
To explore the risk factors of recurrence within 1 year after radical resection of non-small cell lung cancer (NSCLC) and construct the nomogram model.
The clinical data of 186 patients with NSCLC treated with radical surgery in Affiliated Hospital of Youjiang Medical University for Nationalities of Baise were retrospectively analyzed. Multivariate logistic regression was applied to analyze the risk factors of recurrence within 1 year after radical resection of NSCLC. The R language (R 4.0.3 software package) was used in constructing the nomogram model, and the predictive value of the model was evaluated.
The recurrence rate of 186 patients within 1 year after radical surgery was 29.57%. After multivariate logistic regression analysis, pathological stage, number of lymph node metastasis, chronic obstructive pulmonary disease (COPD), postoperative plasma D-dimer, and carcinoembryonic antigen were independent factors for recurrence within 1 year after radical resection of NSCLC ( < 0.05). Based on the above independent risk factors, a nomogram model was established, with the distinction of AUC = 0.891 (95% CI: 0.819-0.964) and sensitivity and specificity of 70.3% and 97.8%, respectively. The calibration curve was close to the ideal curve. External validation of the model showed AUC = 0.801 (95% CI: 0.674-0.928), and sensitivity and specificity were 66.7% and 84.2%, respectively.
The recurrence of NSCLC within 1 year after radical surgery was related to a variety of factors, and the nomogram model constructed based on risk factors had good goodness of fit, calibration, consistency of prediction, and prediction efficiency.
探讨非小细胞肺癌（NSCLC）根治性切除术后1年内复发的危险因素并构建列线图模型。
回顾性分析百色右江民族医学院附属医院186例行根治性手术的NSCLC患者的临床资料。采用多因素logistic回归分析NSCLC根治性切除术后1年内复发的危险因素。运用R语言（R 4.0.3软件包）构建列线图模型并评估模型的预测价值。
186例患者根治性手术后1年内的复发率为29.57%。多因素logistic回归分析显示，病理分期、淋巴结转移数目、慢性阻塞性肺疾病（COPD）、术后血浆D-二聚体及癌胚抗原是NSCLC根治性切除术后1年内复发的独立因素（<0.05）。基于上述独立危险因素建立列线图模型，其AUC为0.891（95%CI：0.819-0.964），敏感度和特异度分别为70.3%和97.8%。校准曲线接近理想曲线。模型的外部验证显示AUC为0.801（95%CI：0.674-0.928），敏感度和特异度分别为66.7%和84.2%。
NSCLC根治性手术后1年内的复发与多种因素有关，基于危险因素构建的列线图模型具有良好的拟合优度、校准度、预测一致性和预测效率。
