Zhou Jing, Diao Xin, Wang Shengyu, Yao Yang
Department of Respiratory and Critical Care, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, People's Republic of China.
Cancer Manag Res. 2020 Sep 22;12:8813-8819. doi: 10.2147/CMAR.S268565. eCollection 2020.
The aim of this study was to evaluate the clinical diagnostic value of combined detection of serum ferritin (SF), carcino-embryonic antigen (CEA) and C-reactive protein (CRP) in non-small cell lung cancer (NSCLC).
The study included 70 patients with NSCLC, 50 patients with benign lung disease and 50 healthy subjects. The serum concentrations of SF, CEA and CRP were determined by ELISA.
The results showed that the serum levels of SF, CEA and CRP in the NSCLC group were significantly higher than those of the benign lung disease group and the control group. The expression of the above three indexes in the lung cancer group III+IV was higher than that in the I+II group (<0.05), and the expression of SF, CEA and CRP in the adenocarcinoma group was higher than that in the squamous cell carcinoma group. The difference is statistically significant (<0.01). When the serum CEA, SF and CRP levels were used alone for diagnosis of NSCLC, CRP had the best diagnostic value. The area under the curve was 0.795. The diagnostic sensitivity and specificity were 81.8% and 66.8%, respectivelyWhen combining these three factors, the area under the curve was 0.890, and the sensitivity and specificity were 80.3% and 82.5%, respectively. The parameters above were also significantly different (all <0.01).
This study indicated that the combined detection of serum SF, CEA and CRP could improve the early diagnostic sensitivity of NSCLC, and may be used as a potential diagnostic method for NSCLC.
本研究旨在评估血清铁蛋白（SF）、癌胚抗原（CEA）和C反应蛋白（CRP）联合检测在非小细胞肺癌（NSCLC）中的临床诊断价值。
本研究纳入70例NSCLC患者、50例良性肺病患者和50例健康受试者。采用酶联免疫吸附测定法（ELISA）测定血清中SF、CEA和CRP的浓度。
结果显示，NSCLC组血清SF、CEA和CRP水平显著高于良性肺病组和对照组。肺癌Ⅲ+Ⅳ期组上述三项指标的表达高于Ⅰ+Ⅱ期组（<0.05），腺癌组SF、CEA和CRP的表达高于鳞癌组，差异有统计学意义（<0.01）。单独使用血清CEA、SF和CRP水平诊断NSCLC时，CRP具有最佳诊断价值。曲线下面积为0.795，诊断敏感性和特异性分别为81.8%和66.8%。联合这三个因素时，曲线下面积为0.890，敏感性和特异性分别为80.3%和82.5%。上述参数也有显著差异（均<0.01）。
本研究表明，血清SF、CEA和CRP联合检测可提高NSCLC的早期诊断敏感性，可能作为NSCLC的一种潜在诊断方法。
