Pan Yunfeng, Liu Jia, Ren Jiahui, Luo Yun, Sun Xiaobo
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China.
Front Pharmacol. 2022 Jul 14;13:929152. doi: 10.3389/fphar.2022.929152. eCollection 2022.
Vascular diseases affect the circulatory system and comprise most human diseases. They cause severe symptoms and affect the quality of life of patients. Recently, since their identification, exchange proteins directly activated by cAMP (Epac) have attracted increasing scientific interest, because of their role in cyclic adenosine monophosphate (cAMP) signaling, a well-known signal transduction pathway. The role of Epac in cardiovascular disease and cancer is extensively studied, whereas their role in kidney disease has not been comprehensively explored yet. In this study, we aimed to review recent studies on the regulatory effects of Epac on various vascular diseases, such as cardiovascular disease, cerebrovascular disease, and cancer. Accumulating evidence has shown that both Epac1 and Epac2 play important roles in vascular diseases under both physiological and pathological conditions. Additionally, there has been an increasing focus on Epac pharmacological modulators. Therefore, we speculated that Epac could serve as a novel therapeutic target for the treatment of vascular diseases.
血管疾病影响循环系统，并且构成了大多数人类疾病。它们会引发严重症状并影响患者的生活质量。最近，自环磷酸腺苷（cAMP）直接激活的交换蛋白（Epac）被发现以来，因其在环磷酸腺苷（cAMP）信号传导（一种著名的信号转导途径）中的作用，引起了越来越多的科学关注。Epac在心血管疾病和癌症中的作用已得到广泛研究，而它们在肾脏疾病中的作用尚未得到全面探索。在本研究中，我们旨在综述Epac对各种血管疾病（如心血管疾病、脑血管疾病和癌症）调节作用的最新研究。越来越多的证据表明，Epac1和Epac2在生理和病理条件下的血管疾病中均发挥重要作用。此外，对Epac药理调节剂的关注也日益增加。因此，我们推测Epac可作为治疗血管疾病的新型治疗靶点。
