Whitaker Alicen A, Henry Madison L, Morton Allegra, Ward Jaimie L, Eickmeyer Sarah M, Abraham Michael G, Billinger Sandra A
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS.
Department of Physical Medicine and Rehabilitation, University of Kansas Medical Center, Kansas City, KS.
Cardiopulm Phys Ther J. 2022 Jul;33(3):130-137. doi: 10.1097/CPT.0000000000000196. Epub 2022 Mar 25.
Physical activity within the hospital post-stroke is recommended for cardiovascular and musculoskeletal health, but no studies have examined cerebrovascular health. We hypothesized individuals who walked farther distances (FARhigh) during the acute phase of stroke recovery in a hospital setting would have a higher resting middle cerebral artery blood velocity (MCAv) and a greater cerebrovascular response (CVR) to moderate-intensity exercise at 3-months post-stroke, compared to individuals who walked shorter distances (FARlow).
At 3-month post-stroke, we recorded 90-seconds of resting baseline (BL) MCAv followed by 6-minutes of moderate-intensity exercise. We calculated CVR as the change in MCAv from BL to steady-state exercise. We collected farthest distance walked within the hospital post-stroke from the electronic medical record. Participants were classified as FARhigh or FARlow based on average farthest walking distance.
Twenty participants completed the study, age 63 (15) years. BL MCAv was not different between groups (p = 0.07). In comparison to FARlow, we report a higher CVR in FARhigh's ipsilesional ( = 7.38 (5.42) vs = 2.19 (3.53), p = 0.02) and contralesional hemisphere ( = 8.15 (6.37) vs = 2.06 (4.76), p = 0.04).
Physical activity during the hospital stay post-stroke may support cerebrovascular health after discharge. Prospective studies are needed to support this finding.
推荐中风后在医院内进行体育活动以促进心血管和肌肉骨骼健康，但尚无研究考察其对脑血管健康的影响。我们假设，在医院中风恢复急性期行走距离较远（FARhigh）的个体，与行走距离较短（FARlow）的个体相比，在中风后3个月时，其静息大脑中动脉血流速度（MCAv）更高，对中等强度运动的脑血管反应（CVR）更大。
在中风后3个月时，我们记录了90秒的静息基线（BL）MCAv，随后进行6分钟的中等强度运动。我们将CVR计算为MCAv从BL到稳态运动的变化。我们从电子病历中收集了中风后在医院内行走的最远距离。根据平均最远距离将参与者分为FARhigh或FARlow。
20名参与者完成了研究，年龄63（15）岁。两组之间的BL MCAv无差异（p = 0.07）。与FARlow相比，我们发现FARhigh患侧半球（= 7.38（5.42）vs = 2.19（3.53），p = 0.02）和对侧半球（= 8.15（6.37）vs = 2.06（4.76），p = 0.04）的CVR更高。
中风后住院期间的体育活动可能有助于出院后的脑血管健康。需要前瞻性研究来支持这一发现。
