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儿童肝细胞癌的管理

Managing Hepatocellular Carcinoma in Children.

作者信息

Shaukat Zunaira, Imtiaz Mehwish, Naqeeb Rawaha, Seerat Iqtadar, Atique Muhammad, Dar Faisal

机构信息

Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Pediatric Gastroenterology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK.

出版信息

Cureus. 2022 Jun 28;14(6):e26386. doi: 10.7759/cureus.26386. eCollection 2022 Jun.

DOI:10.7759/cureus.26386
PMID:35911356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9336830/
Abstract

Hepatocellular carcinoma (HCC) is a rare pediatric tumor. It differs from its adult counterpart in many ways like etiology, biological behavior, and association with cirrhosis. Treating HCC requires a multidisciplinary team involving pediatric gastroenterology, oncology, hepatobiliary surgery, and interventional radiology. This case series aims to describe presenting features and management plan of three children with HCC treated at a tertiary care liver transplant center in Pakistan.

摘要

肝细胞癌（HCC）是一种罕见的儿科肿瘤。它在病因、生物学行为以及与肝硬化的关联等许多方面与其成人对应物有所不同。治疗HCC需要一个多学科团队，包括儿科胃肠病学、肿瘤学、肝胆外科和介入放射学。本病例系列旨在描述在巴基斯坦一家三级医疗肝脏移植中心接受治疗的三名HCC患儿的临床表现和管理方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/6362484e8a98/cureus-0014-00000026386-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/3bf12c9584b2/cureus-0014-00000026386-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/230207d7b626/cureus-0014-00000026386-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/8cfa330cb783/cureus-0014-00000026386-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/6362484e8a98/cureus-0014-00000026386-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/3bf12c9584b2/cureus-0014-00000026386-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/230207d7b626/cureus-0014-00000026386-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/8cfa330cb783/cureus-0014-00000026386-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ea/9336830/6362484e8a98/cureus-0014-00000026386-i04.jpg

相似文献

1
Managing Hepatocellular Carcinoma in Children.儿童肝细胞癌的管理
Cureus. 2022 Jun 28;14(6):e26386. doi: 10.7759/cureus.26386. eCollection 2022 Jun.
2
The importance of a multidisciplinary approach to hepatocellular carcinoma.多学科方法对肝细胞癌的重要性。
J Multidiscip Healthc. 2017 Mar 20;10:95-100. doi: 10.2147/JMDH.S128629. eCollection 2017.
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Role of interventional radiology in managing pediatric liver tumors : Part 1: Endovascular interventions.介入放射学在小儿肝脏肿瘤治疗中的作用：第1部分：血管内介入治疗
Pediatr Radiol. 2018 Apr;48(4):555-564. doi: 10.1007/s00247-018-4068-1. Epub 2018 Jan 23.
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Multidisciplinary Management of Patients with Unresectable Hepatocellular Carcinoma: A Critical Appraisal of Current Evidence.不可切除肝细胞癌患者的多学科管理：当前证据的批判性评估
Cancers (Basel). 2019 Jun 22;11(6):873. doi: 10.3390/cancers11060873.
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Prior Trans-arterial chemoembolization - A protective factor against rapid HCV recurrence post liver transplant in patients with HCV with HCC? - A Retrospective Cohort Study.经动脉化疗栓塞术——对伴有 HCC 的 HCV 患者肝移植术后 HCV 快速复发的保护因素？——一项回顾性队列研究。
Int J Surg. 2016 Jun;30:132-5. doi: 10.1016/j.ijsu.2016.04.050. Epub 2016 May 4.
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Radiological appearance of hepatocellular carcinoma predicts the response to trans-arterial chemoembolization in patients undergoing liver transplantation.肝癌的放射学表现可预测行肝移植患者接受经动脉化疗栓塞治疗的反应。
BMC Cancer. 2019 Nov 5;19(1):1041. doi: 10.1186/s12885-019-6265-1.
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Role of liver transplantation for hepatocellular carcinoma.肝移植在肝细胞癌治疗中的作用。
J Clin Exp Hepatol. 2014 Aug;4(Suppl 3):S97-S103. doi: 10.1016/j.jceh.2014.01.002. Epub 2014 Jan 23.
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Tumor response to transcatheter arterial chemoembolization in recurrent hepatocellular carcinoma after living donor liver transplantation.活体肝移植术后复发性肝细胞癌经导管动脉化疗栓塞术的肿瘤反应
Korean J Radiol. 2007 Jul-Aug;8(4):320-7. doi: 10.3348/kjr.2007.8.4.320.
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A comparison of chemoembolization with conventional chemotherapy and symptomatic treatment in cirrhotic patients with hepatocellular carcinoma.肝细胞癌肝硬化患者中化疗栓塞与传统化疗及对症治疗的比较。
Hepatogastroenterology. 1996 May-Jun;43(9):681-7.
10
Resectability of hepatocellular carcinoma: evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature.肝细胞癌的可切除性：单肝胆专科中心333例连续病例的评估及文献系统综述
Hepatogastroenterology. 2006 May-Jun;53(69):322-9.

本文引用的文献

1
Accumulation of trace elements in muscle, gill and liver of fish species (Capoeta umbla and Luciobarbus mystaceus) in the Tigris River (Turkey), and health risk assessment.鱼类（乌鳢和拟腹吸鳅）肌肉、鳃和肝脏中微量元素的积累及其在底格里斯河（土耳其）的分布情况，以及健康风险评估。
Environ Res. 2020 Jul;186:109570. doi: 10.1016/j.envres.2020.109570. Epub 2020 Apr 21.
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Pediatric hepatocellular carcinoma.小儿肝细胞癌。
World J Gastroenterol. 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980.
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A review of 218 pediatric cases of hepatocellular carcinoma.
218 例小儿肝细胞癌病例回顾。
J Pediatr Surg. 2014 Jan;49(1):166-71; discussion 171. doi: 10.1016/j.jpedsurg.2013.09.050. Epub 2013 Oct 5.
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Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium.迈向国际小儿肝肿瘤共识分类：洛杉矶 COG 肝肿瘤研讨会会议记录。
Mod Pathol. 2014 Mar;27(3):472-91. doi: 10.1038/modpathol.2013.80. Epub 2013 Sep 6.
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Favorable outcome of primary liver transplantation in children with cirrhosis and hepatocellular carcinoma.肝硬化和肝细胞癌患儿初次肝移植的良好预后。
Pediatr Transplant. 2011 Sep;15(6):573-9. doi: 10.1111/j.1399-3046.2011.01528.x. Epub 2011 Jul 29.
6
Liver transplantation in children with hepatocellular carcinoma. Do Milan criteria apply to pediatric patients?肝细胞癌患儿的肝移植。米兰标准适用于儿科患者吗？
Pediatr Transplant. 2009 Sep;13(6):682-92. doi: 10.1111/j.1399-3046.2009.01062.x. Epub 2009 May 21.
7
Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors.肝母细胞瘤的小细胞未分化变异型：与横纹肌样肿瘤相似的不良临床和分子特征
Pediatr Blood Cancer. 2009 Mar;52(3):328-34. doi: 10.1002/pbc.21834.
8
Hepatocellular carcinoma and liver tumors in South African children: a case for increased prevalence.南非儿童的肝细胞癌和肝脏肿瘤：患病率上升情况
Cancer. 2004 Aug 1;101(3):642-9. doi: 10.1002/cncr.20398.
9
Adult type vs. Childhood hepatocellular carcinoma--are they the same or different lesions? Biology, natural history, prognosis, and treatment.成人型与儿童型肝细胞癌——它们是相同还是不同的病变？生物学特性、自然史、预后及治疗
Med Pediatr Oncol. 2002 Nov;39(5):519-23. doi: 10.1002/mpo.10178.
10
Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group.儿童肝细胞癌：国际小儿肿瘤学会组首次前瞻性研究结果
J Clin Oncol. 2002 Jun 15;20(12):2798-804. doi: 10.1200/JCO.2002.06.102.