共同性外斜视患者低频波动幅度的时间动态改变
Altered Temporal Dynamics of the Amplitude of Low-Frequency Fluctuations in Comitant Exotropia Patients.
作者信息
Chen Ri-Bo, Ye Shu-Yuan, Pei Chong-Gang, Zhong Yu-Lin
机构信息
Department of Radiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Department of Ophthalmology, The First Affiliated of Nanchang University, Nanchang, China.
出版信息
Front Hum Neurosci. 2022 Jul 13;16:944100. doi: 10.3389/fnhum.2022.944100. eCollection 2022.
PURPOSE
Growing evidence reported that patients with comitant exotropia (CE) were accompanied by static cerebral neural activity changes. However, whether the dynamic time-varying of neural activity changes in patients with CE remains unknown.
METHODS
A total of 36 patients with CE (25 men and 11 women) and 36 well-matched healthy controls are enrolled in the study. The dynamic amplitude of low-frequency fluctuation (dALFF) combined with the sliding window method was used to assess the dynamic neural activity changes in patients with CE.
RESULTS
Compared with HCs, patients with CE had decreased dALFF values in the right superior parietal lobule (SPL) and right precuneus gyrus (PreCUN). Moreover, we found that the dALFF maps showed an accuracy of 48.61% and an area under the curve of.54 for distinguishing the patients with CE from HCs.
CONCLUSION
Our study demonstrated that patients with CE showed altered dynamic neural activity changes in the right SPL and right PreCUN, which might indicate the neuropathological mechanism of stereoscopic dysfunction in patients with CE.
目的
越来越多的证据表明，共同性外斜视（CE）患者伴有静态脑神经网络活动变化。然而，CE患者神经活动变化的动态时变情况仍不清楚。
方法
本研究共纳入36例CE患者（25例男性，11例女性）和36例匹配良好的健康对照者。采用结合滑动窗口法的低频波动动态幅度（dALFF）来评估CE患者的动态神经活动变化。
结果
与健康对照者相比，CE患者右侧顶上小叶（SPL）和右侧楔前回（PreCUN）的dALFF值降低。此外，我们发现dALFF图谱区分CE患者和健康对照者的准确率为48.61%，曲线下面积为0.54。
结论
我们的研究表明，CE患者右侧SPL和右侧PreCUN的动态神经活动变化存在改变，这可能提示了CE患者立体视功能障碍的神经病理机制。
Zotero 插件