Jeong Seung-Hwan, Han Jang Hee, Jeong Chang Wook, Kim Hyeon Hoe, Kwak Cheol, Yuk Hyeong Dong, Ku Ja Hyeon
Department of Urology, Seoul National University Hospital, Seoul, South Korea.
Department of Urology, Seoul National University College of Medicine, Seoul, South Korea.
Front Oncol. 2022 Jul 14;12:858813. doi: 10.3389/fonc.2022.858813. eCollection 2022.
Upper tract urothelial carcinoma (UTUC) occurs in urothelial cells from the kidney and the ureters. Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker for pancreatic and gastrointestinal cancers, and its high levels are associated with poor prognosis in bladder cancer. In this study, prospective patients enrolled in the registry of Seoul National University were retrospectively examined to determine the clinical significance of CA 19-9 in UTUC. In 227 patients, high serum CA 19-9 levels reflected a high tumor burden represented by high T and N stages, leading to adverse prognosis in metastasis-free or overall survival. Subsequently, propensity score matching analysis showed that the CA 19-9 level is an independent prognostic factor of UTUC.
上尿路尿路上皮癌（UTUC）发生于肾脏和输尿管的尿路上皮细胞。糖类抗原19-9（CA 19-9）是胰腺癌和胃肠道癌的肿瘤标志物，其高水平与膀胱癌的不良预后相关。在本研究中，对纳入首尔国立大学登记处的前瞻性患者进行回顾性检查，以确定CA 19-9在UTUC中的临床意义。在227例患者中，血清CA 19-9高水平反映了由高T和N分期所代表的高肿瘤负荷，导致无转移生存或总生存的不良预后。随后，倾向评分匹配分析表明，CA 19-9水平是UTUC的独立预后因素。
