Chen Xing, Chen Yan, Liu Yikun, Zou Liqiang, McClements David Julian, Liu Wei
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
School of Life Sciences, Nanchang University, Nanchang, China.
Compr Rev Food Sci Food Saf. 2022 Sep;21(5):3963-4001. doi: 10.1111/1541-4337.13017. Epub 2022 Aug 1.
Increasing awareness of the health benefits of specific constituents in fruits, vegetables, cereals, and other whole foods has sparked a broader interest in the potential health benefits of nutraceuticals. Many nutraceuticals are hydrophobic substances, which means they must be encapsulated in colloidal delivery systems. Oil-in-water emulsions are one of the most widely used delivery systems for improving the bioavailability and bioactivity of these nutraceuticals. The composition and structure of emulsions can be designed to improve the water dispersibility, physicochemical stability, and bioavailability of the encapsulated nutraceuticals. The nature of the emulsion used influences the interfacial area and properties of the nutraceutical-loaded oil droplets in the gastrointestinal tract, which influences their digestion, as well as the bioaccessibility, metabolism, and absorption of the nutraceuticals. In this article, we review recent in vitro and in vivo studies on the utilization of emulsions to improve the bioavailability of nutraceuticals. The findings from this review should facilitate the design of more efficacious nutraceutical-loaded emulsions with increased bioactivity.
人们对水果、蔬菜、谷物及其他天然食品中特定成分的健康益处的认识不断提高，引发了对营养保健品潜在健康益处的更广泛兴趣。许多营养保健品是疏水性物质，这意味着它们必须被封装在胶体递送系统中。水包油乳液是提高这些营养保健品生物利用度和生物活性最广泛使用的递送系统之一。乳液的组成和结构可以设计成提高被封装营养保健品的水分散性、物理化学稳定性和生物利用度。所用乳液的性质会影响胃肠道中负载营养保健品的油滴的界面面积和性质，这会影响它们的消化，以及营养保健品的生物可及性、代谢和吸收。在本文中，我们综述了最近关于利用乳液提高营养保健品生物利用度的体外和体内研究。这篇综述的结果应有助于设计出具有更高生物活性、更有效的负载营养保健品的乳液。
