Siaens A, De Rood M
Acta Anaesthesiol Belg. 1987;38(1):89-95.
We studied the effects of three different solutions of bupivacaine, injected intrathecally. Each solution had a volume of 3 ml and differed from the others by its mass or its baricity. Sixty-five patients, divided into three groups, remained in the sitting position for one minute after injection of the tested solutions. Group 1 received 10 mg of hyperbaric bupivacaine, group 2 received 10 mg of isobaric bupivacaine and group 3 received 15 mg of isobaric bupivacaine. Groups 1 and 2 showed no statistical difference in maximal extension of analgesia (T 11 and T 10), nor in mean duration of analgesia (155 and 159 min.). The motor block was similar in both groups (score less than 2 using the Bromage scale 0-3). Group 3 had a higher level of maximal cephalad extension and a longer mean duration of analgesia (186 min.). The motor block was more pronounced after 30 min. (85% score 3) compared to the two other groups. The decrease in mean arterial pressure was moderate and similar in the three groups. In view of the results of this study, we suggest the use of 3 ml of 0.5% isobaric bupivacaine injected intrathecally.
我们研究了经鞘内注射三种不同布比卡因溶液的效果。每种溶液体积为3毫升，在质量或比重上与其他溶液不同。65名患者分为三组，在注射受试溶液后保持坐位1分钟。第1组接受10毫克重比重布比卡因，第2组接受10毫克等比重布比卡因，第3组接受15毫克等比重布比卡因。第1组和第2组在镇痛的最大范围（T11和T10）以及平均镇痛持续时间（155分钟和159分钟）方面无统计学差异。两组的运动阻滞相似（使用Bromage 0 - 3评分量表，评分低于2分）。第3组的最大头侧延伸水平更高，平均镇痛持续时间更长（186分钟）。与其他两组相比，30分钟后运动阻滞更明显（85%评分为3分）。三组平均动脉压的下降程度适中且相似。鉴于本研究结果，我们建议鞘内注射3毫升0.5%等比重布比卡因。
