Solti F, Iskum M, Váradi A
Acta Physiol Hung. 1987;69(1):15-9.
In the course of long lasting bradycardia in elderly patients, cardiac output will regularly diminish, circulation will slow down and signs of cerebral insufficiency may become manifest. The changes of cerebral circulation and its regulation were studied in 10 patients 61-74 years of age, with restricted cerebral regulatory capacity, suffering from permanent bradycardia. Cerebral blood flow was measured by using the venous isotope dilution technique by double punctures of the internal jugular vein. Hemispheric cerebral blood flow, cerebral O2 consumption and cerebral vascular resistance were determined during bradycardia and after termination of bradycardia by pacemaker. During long lasting bradycardia, cerebral blood flow and cerebral O2 consumption decreased, cerebral vascular resistance was elevated. After pacemaker implantation, cerebral blood flow and O2 consumption increased and cerebral vascular resistance decreased, approaching the normal value. The symptoms of cerebral insufficiency disappeared on improvement of the cerebral circulation.
在老年患者长期心动过缓的过程中，心输出量会经常减少，循环会减慢，脑供血不足的症状可能会显现出来。对10名年龄在61 - 74岁、脑调节能力受限且患有永久性心动过缓的患者的脑循环及其调节变化进行了研究。通过颈内静脉双穿刺采用静脉同位素稀释技术测量脑血流量。在心动过缓期间以及通过起搏器终止心动过缓后，测定半球脑血流量、脑氧耗量和脑血管阻力。在长期心动过缓期间，脑血流量和脑氧耗量降低，脑血管阻力升高。植入起搏器后，脑血流量和氧耗量增加，脑血管阻力降低，接近正常值。随着脑循环的改善，脑供血不足的症状消失。
