Korolkiewicz Z, Poćwiardowska-Ciara E
Acta Physiol Pol. 1986 Jul-Aug;37(4-5):177-82.
The effects of vitamin C and acetylcholine on the smooth muscle of rat stomach were compared after neomycin-induced blockade of phosphatidylinositol metabolism. The cumulative curves of dose-dependent responses showed a non-competitive antagonism between vitamin C and neomycin. On the other hand, the antagonism between acetylcholine and neomycin was of a mixed, competitive-non-competitive type. The results of the experiments suggest the conclusion that a normal metabolism of phosphatidylinositol controlling calcium transport into the cells is necessary for the stimulating effect of vitamin C on the contractions of the smooth muscles in the digestive tract.
在新霉素诱导的磷脂酰肌醇代谢阻断后，比较了维生素C和乙酰胆碱对大鼠胃平滑肌的影响。剂量依赖性反应的累积曲线显示维生素C和新霉素之间存在非竞争性拮抗作用。另一方面，乙酰胆碱和新霉素之间的拮抗作用是混合的、竞争性-非竞争性类型。实验结果提示结论：控制钙进入细胞的磷脂酰肌醇正常代谢对于维生素C对消化道平滑肌收缩的刺激作用是必要的。
