Children's Mercy Hospital, The University of Missouri-Kansas City, Kansas City.
Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus.
JAMA Pediatr. 2022 Sep 1;176(9):852-859. doi: 10.1001/jamapediatrics.2022.2663.
Bronchopulmonary dysplasia (BPD) is the most common serious morbidity of preterm birth. Short-term respiratory outcomes for infants with the most severe forms of BPD are highly variable. The mechanisms that explain this variability remain unknown and may be mediated by racial disparities.
To determine the association of maternal race with death and length of hospital stay in a multicenter cohort of infants with severe BPD.
DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study included preterm infants enrolled in the BPD Collaborative registry from January 1, 2015, to July 19, 2021, involving 8 BPD Collaborative centers located in the US. Included patients were born at less than 32 weeks' gestation, had a diagnosis of severe BPD as defined by the 2001 National Institutes of Health Consensus Criteria, and were born to Black or White mothers.
Maternal race: Black vs White.
Death and length of hospital stay.
Among 834 registry infants (median [IQR] gestational age, 25 [24-27] weeks; 492 male infants [59%]) meeting inclusion criteria, the majority were born to White mothers (558 [67%]). Death was observed infrequently in the study cohort (32 [4%]), but Black maternal race was associated with an increased odds of death (adjusted odds ratio, 2.1; 95% CI, 1.2-3.5) after adjusting for center. Black maternal race was also significantly associated with length of hospital stay (adjusted between-group difference, 10 days; 95% CI, 3-17 days).
In a multicenter severe BPD cohort, study results suggest that infants born to Black mothers had increased likelihood of death and increased length of hospital stay compared with infants born to White mothers. Prospective studies are needed to define the sociodemographic mechanisms underlying disparate health outcomes for Black infants with severe BPD.
支气管肺发育不良（BPD）是早产儿最常见的严重并发症之一。患有最严重形式 BPD 的婴儿的短期呼吸结果差异很大。解释这种差异的机制尚不清楚，可能与种族差异有关。
确定在多中心 BPD 协作登记处的严重 BPD 婴儿队列中，母亲种族与死亡和住院时间的关系。
设计、地点和参与者：这项多中心队列研究纳入了 2015 年 1 月 1 日至 2021 年 7 月 19 日期间在美国 8 个 BPD 协作中心登记的胎龄小于 32 周、根据 2001 年美国国立卫生研究院共识标准诊断为严重 BPD 的早产儿，且母亲为黑人和白人。
母亲种族：黑人与白人。
死亡和住院时间。
在符合纳入标准的 834 名登记婴儿（中位数[IQR]胎龄，25[24-27]周；492 名男性婴儿[59%]）中，大多数母亲为白人（558[67%]）。研究队列中观察到死亡的情况很少见（32[4%]），但黑人母亲种族与死亡的几率增加相关（调整后的优势比，2.1；95%CI，1.2-3.5），调整中心后。黑人母亲种族也与住院时间显著相关（调整后的组间差异，10 天；95%CI，3-17 天）。
在多中心严重 BPD 队列中，研究结果表明，与白人母亲出生的婴儿相比，黑人母亲出生的婴儿死亡的可能性更大，住院时间更长。需要前瞻性研究来确定导致严重 BPD 黑人婴儿健康结果差异的社会人口学机制。
