COVID-19 疫苗接种后穿透性角膜移植术中的急性排斥反应-病例报告及文献复习。
Acute Rejection Following COVID-19 Vaccination in Penetrating Keratoplasty in a Young Male - A Case Report and Review of Literature.
机构信息
Pediatric Ophthalmology Unit A, Meyer Children's Hospital, Florence, Italy.
出版信息
Ocul Immunol Inflamm. 2023 Aug;31(6):1226-1229. doi: 10.1080/09273948.2022.2106248. Epub 2022 Aug 1.
PURPOSE
To report a case of a boy with acute keratoplasty rejection manifesting 12 days after receiving BNT162b2 messenger RNA (mRNA) vaccine for COVID-19.
STUDY DESIGN
A case report.
RESULTS
A 15-year-old boy with a history of penetrating keratoplasty due to acanthamoeba keratitis developed corneal decompensation 12 days after BNT162b2 messenger RNA vaccine for COVID-19 disease. One-week treatment with topical Dexamethasone 2% eye drops resulted in a complete resolution of corneal edema.
CONCLUSIONS
This case suggests that BNT162b2 messenger RNA (mRNA) vaccine can be associated with acute keratoplasty rejection in children, which responds completely to topical steroids. Ophthalmologists should be aware of this risk of cornea decompensation after COVID-19 vaccine in children who received a cornea transplant.
目的
报告 1 例男孩在接种 COVID-19 的 BNT162b2 信使 RNA（mRNA）疫苗 12 天后发生急性角膜移植排斥反应。
研究设计
病例报告。
结果
1 例 15 岁男孩，因棘阿米巴角膜炎行穿透性角膜移植术，在 COVID-19 疾病的 BNT162b2 信使 RNA 疫苗接种后 12 天出现角膜失代偿。局部使用 2%地塞米松滴眼液治疗 1 周后，角膜水肿完全消退。
结论
本病例提示 BNT162b2 信使 RNA（mRNA）疫苗可能与儿童急性角膜移植排斥反应相关，对外用类固醇治疗反应完全。眼科医生应意识到 COVID-19 疫苗接种后儿童角膜移植后角膜失代偿的风险。
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