胺碘酮治疗过程中发生的疼痛性自身免疫性甲状腺炎。

Painful autoimmune thyroiditis occurring on amiodarone therapy.

作者信息

Gudbjörnsson B, Kristinsson A, Geirsson G, Hreidarsson A B

出版信息

Acta Med Scand. 1987;221(2):219-20. doi: 10.1111/j.0954-6820.1987.tb01271.x.

DOI:10.1111/j.0954-6820.1987.tb01271.x

Abstract

A 51-year-old housewife, who had been on treatment with amiodarone for ten months, developed a painful enlargement of the thyroid gland. Thyroid antibody titers were highly elevated and a fine needle aspirate of the gland showed infiltration of lymphocytes and plasma cells. Initially the patient was hyperthyroid, later she developed hyperthyroidism which required thyroid substitution. The possibility of amiodarone provoking autoimmune thyroiditis is discussed.

摘要

一位51岁的家庭主妇，服用胺碘酮治疗10个月后，出现甲状腺疼痛性肿大。甲状腺抗体滴度显著升高，甲状腺细针穿刺显示淋巴细胞和浆细胞浸润。起初患者表现为甲状腺功能亢进，后来发展为甲状腺功能减退，需要甲状腺替代治疗。本文讨论了胺碘酮诱发自身免疫性甲状腺炎的可能性。