Chinese PLA Medical School, Beijing, China; Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Ultrasound Med Biol. 2022 Oct;48(10):2110-2118. doi: 10.1016/j.ultrasmedbio.2022.05.035. Epub 2022 Jul 30.
The aim of this study was to evaluate renal perfusion changes in rats with acute kidney injury induced by rhabdomyolysis, using quantitative parameters obtained with contrast-enhanced ultrasound (CEUS). Sprague-Dawley (SD) rats were randomly divided into an experimental group (n = 40) and a control group (n = 20). Each group was further divided into four subgroups (0.5-, 6-, 24- and 72-h groups). Time-intensity curves and related quantitative parameters of the renal cortex and medulla were obtained by CEUS, and the contrast characteristics analyzed for different time points. In the experimental group, the CEUS quantitative parameters for the renal medulla of time to peak (TTP), descending time/2 (DT/2) and area under the curve (AUC) increased, whereas ascending slope (AS) and descending slope (DS) decreased. Similarly, renal cortical AS, DS and AUC in the experimental group differed significantly from those in the control group. With respect to the CEUS quantitative parameters for the renal cortex, AUC increased, and AS and DS decreased. These parameters differed significantly between the experimental and control groups. CEUS is sensitive to change in renal perfusion in rhabdomyolysis-induced acute kidney injury and, thus, has diagnostic value.
本研究旨在利用对比增强超声（CEUS）获得的定量参数评估横纹肌溶解症诱导的急性肾损伤大鼠的肾脏灌注变化。将 Sprague-Dawley（SD）大鼠随机分为实验组（n=40）和对照组（n=20）。每组进一步分为四个亚组（0.5、6、24 和 72 小时组）。通过 CEUS 获得肾皮质和髓质的时间-强度曲线和相关定量参数，并分析不同时间点的对比特征。在实验组中，肾髓质的峰值时间（TTP）、下降时间/2（DT/2）和曲线下面积（AUC）的 CEUS 定量参数增加，而上升斜率（AS）和下降斜率（DS）降低。同样，实验组的肾皮质 AS、DS 和 AUC 与对照组有显著差异。就肾皮质的 CEUS 定量参数而言，AUC 增加，AS 和 DS 降低。这些参数在实验组和对照组之间有显著差异。CEUS 对横纹肌溶解症诱导的急性肾损伤肾灌注变化敏感，因此具有诊断价值。
