cGAS-STING 和致命的 CIN：慢性炎症如何代表染色体不稳定癌症的治疗弱点。

cGAS-STING and the deadly CIN: how chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers.

机构信息

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Trends Cancer. 2022 Oct;8(10):788-789. doi: 10.1016/j.trecan.2022.07.006. Epub 2022 Jul 29.

DOI:10.1016/j.trecan.2022.07.006

PMID:35915014

Abstract

Chromosomal instability (CIN) is a key genomic driver of human cancer. CIN generates genomic copy-number heterogeneity and tumor-derived inflammation. In a recent paper, Hong et al. identify the cGAS-STING innate immune pathway as a crucial dependency in cancer cells with CIN and pinpoint the IL6/STAT3 axis as a therapeutic vulnerability in these difficult-to-treat tumors.

摘要

染色体不稳定（CIN）是人类癌症的一个关键基因组驱动因素。CIN 会产生基因组拷贝数异质性和肿瘤衍生的炎症。在最近的一篇论文中，Hong 等人确定 cGAS-STING 先天免疫途径是 CIN 癌细胞的关键依赖性，并指出 IL6/STAT3 轴是这些难以治疗的肿瘤的治疗弱点。