新辅助化疗改善膀胱癌的免疫抑制微环境并提高免疫检查点阻断的敏感性。
Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade.
机构信息
Department of Oncology, Army Medical Center, Chongqing 400042, China.
Department of Urology, Army Medical Center, Chongqing 400042, China.
出版信息
J Immunol Res. 2022 Jul 21;2022:9962397. doi: 10.1155/2022/9962397. eCollection 2022.
Although tumor immune microenvironment plays an important role in antitumor therapy, few studies explored the gene signatures associated with the tumor immune microenvironment of bladder cancer after neoadjuvant chemotherapy. We examined and analyzed differentially expressed genes from 9 patients with stage I-III bladder cancer by RNA immune-oncology profiling platform. After neoadjuvant chemotherapy, the expressions of 43 genes in 19 pathways and 10 genes in 5 pathways were upregulated and downregulated, respectively. Neoadjuvant chemotherapy also promoted the expression of genes related to the activation of antitumor immune responses and decreased the expression of genes related to tumor proliferation pathways. In addition, neoadjuvant chemotherapy improved tumor response to immune checkpoint blockade. Furthermore, this study also identified several genes that can be used to predict the efficacy of neoadjuvant chemotherapy and their possible molecular mechanisms. In conclusion, neoadjuvant chemotherapy may promote the activation of antitumor effects, improve the suppressive tumor immune microenvironment, and increase the sensitivity of bladder cancer to immune checkpoint blockade.
尽管肿瘤免疫微环境在抗肿瘤治疗中起着重要作用，但很少有研究探讨新辅助化疗后膀胱癌肿瘤免疫微环境相关的基因特征。我们通过 RNA 免疫肿瘤学分析平台，对 9 例 I-III 期膀胱癌患者的差异表达基因进行了检测和分析。新辅助化疗后，19 条通路中的 43 个基因和 5 条通路中的 10 个基因分别上调和下调。新辅助化疗还促进了与抗肿瘤免疫反应激活相关的基因表达，降低了与肿瘤增殖途径相关的基因表达。此外，新辅助化疗提高了肿瘤对免疫检查点阻断的反应。此外，本研究还鉴定了一些可用于预测新辅助化疗疗效及其可能的分子机制的基因。总之，新辅助化疗可能会促进抗肿瘤作用的激活，改善抑制性肿瘤免疫微环境，并增加膀胱癌对免疫检查点阻断的敏感性。
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