动态对比增强 MRI 半定量分析评估肺癌化疗的早期反应。
Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI.
机构信息
Department of Radiology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213002, China.
Department of Radiology, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213002, China.
出版信息
Dis Markers. 2022 Jul 23;2022:2669281. doi: 10.1155/2022/2669281. eCollection 2022.
OBJECTIVE
To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI).
METHODS
Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time points: before starting treatment and after one week of therapy. The image data were collected by DCE-MRI, and the semiquantitative parameters including positive enhancement integral (PEI), signal enhancement ratio (SER), maximum slope of increase (MSI), and time to peak (TTP) were calculated. After chemotherapy, the parameters and relevant variations between the responders and nonresponders were compared with Mann-Whitney tests. Student's -test for paired samples was used to evaluate the temporal changes between pre- and posttreatment images.
RESULTS
The patients were categorized as 13 responders and 9 nonresponders based on the tumor response evaluation. After chemotherapy, the PEI, SER, and MSI were significantly increased in responders compared with the pretreatment values ( < 0.05), while no obvious decrease in TTP was observed ( > 0.05). However, 9 nonresponders showed no significant changes in PEI, SER, MSI, and TTP values, as compared with those of pretreatment ( > 0.05). Moreover, the increase of PEI was more dramatically in responders than in nonresponders ( < 0.05), but no significantly differences were observed in SER, MSI, and TTP ( > 0.05).
CONCLUSION
Semiquantitative analysis of DCE-MRI could provide a reliable noninvasive method for assessing early chemotherapy response in lung cancer patients.
目的
利用动态对比增强磁共振成像（DCE-MRI）的半定量分析来评估肺癌患者的早期化疗反应。
方法
对 22 例接受化疗的肺癌患者在两个时间点进行 DCE-MRI 检查：治疗前和治疗后一周。通过 DCE-MRI 采集图像数据，并计算出阳性增强积分（PEI）、信号增强比（SER）、最大斜率增加（MSI）和达峰时间（TTP）等半定量参数。在化疗后，使用 Mann-Whitney U 检验比较应答者和无应答者之间的参数和相关变化。采用配对样本 t 检验评估治疗前后图像的时间变化。
结果
根据肿瘤反应评估，将患者分为 13 名应答者和 9 名无应答者。化疗后，应答者的 PEI、SER 和 MSI 与治疗前相比明显增加（<0.05），而 TTP 无明显下降（>0.05）。然而，9 名无应答者的 PEI、SER、MSI 和 TTP 值与治疗前相比无明显变化（>0.05）。此外，应答者的 PEI 增加幅度明显大于无应答者（<0.05），但 SER、MSI 和 TTP 之间无显著差异（>0.05）。
结论
DCE-MRI 的半定量分析可为评估肺癌患者的早期化疗反应提供一种可靠的无创方法。
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