头颈部癌症放疗患者身体成分与生存的关联。
Association between body composition and survival in head and neck cancer patients undergoing radiotherapy.
作者信息
Zhuang Bing, Xiao Shaowen, Zhang Lichuan, Wang Yujie, Zhang Tong, Jin Shuai, Jin Sanli, Huang Zhou, Zhao Dan, Gong Liqing, Liu Weixin, Xu Xiaolong, Zheng Baomin, Sun Yan, Lu Qian
机构信息
Division of Medical and Surgical Nursing, School of Nursing, Peking University, Beijing, China.
Department of Radiation Oncology, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, China.
出版信息
Head Neck. 2022 Sep;44(9):2046-2054. doi: 10.1002/hed.27065.
BACKGROUND
Body composition may influence the prognosis of head and neck cancer (HNC) patients. To find out the most crucial factors in this relationship, we explored the association between body composition and survival.
METHODS
In this prospective longitudinal study, HNC patients who underwent radiotherapy (RT) from March 2017 to December 2018 were recruited. The association between body composition and survival was analyzed using Cox proportional hazard regression.
RESULTS
Final analysis included 316 patients, with a median follow-up of 34.4 months. Multivariable analysis revealed that weight loss 6 months before RT and body composition changes during RT did not affect the survival outcome. However, patients with low appendicular skeletal muscle mass index (ASMI) before RT exhibited poor overall survival (OS). ASMI before RT was an independent prognostic factor for OS.
CONCLUSIONS
Body composition loss was common during RT, and ASMI before RT independently influenced the survival outcomes of HNC patients.
背景
身体组成可能影响头颈癌（HNC）患者的预后。为了找出这种关系中最关键的因素，我们探讨了身体组成与生存率之间的关联。
方法
在这项前瞻性纵向研究中，招募了2017年3月至2018年12月接受放射治疗（RT）的HNC患者。使用Cox比例风险回归分析身体组成与生存率之间的关联。
结果
最终分析纳入316例患者，中位随访时间为34.4个月。多变量分析显示，放疗前6个月体重减轻以及放疗期间身体组成变化不影响生存结果。然而，放疗前四肢骨骼肌质量指数（ASMI）低的患者总生存期（OS）较差。放疗前ASMI是OS的独立预后因素。
结论
放疗期间身体组成丢失很常见，放疗前ASMI独立影响HNC患者的生存结果。
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