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坏死性巩膜炎由 引起。

Necrotizing scleritis due to .

机构信息

Department of Ophthalmology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

Department of Microbiology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

出版信息

Eur J Ophthalmol. 2023 Sep;33(5):NP71-NP74. doi: 10.1177/11206721221118209. Epub 2022 Aug 2.

Abstract

PURPOSE

To report the management and outcome of a case of necrotizing scleritis due to .

METHODS

Case report.

RESULTS

A 79-year-old woman developed scleral inflammation following accidental trauma with a gorse plant in her left eye. An abscess formed at the site of the injury, which was surgically drained. Filamentous fungi were identified from the abscess contents, and oral voriconazole and topical voriconazole and natamycin drops were prescribed. Phenotypic analysis confirmed the presence of , with low minimum inhibitory concentrations (MIC) for voriconazole and amphotericin B. Two weeks later the patient presented with an area of necrotizing scleritis which required surgical debridement and scleral grafting. Three months later, the scleral inflammation had resolved leaving an area of scleromalacia.

CONCLUSIONS

is a common environmental fungus that has recently emerged as a human pathogen and a rare cause of scleritis. To the best of our knowledge, this is the first report of scleritis in which a pure culture of was obtained. Successful management poses a challenge as there are limited reports on antifungal susceptibility and a combination of medical and surgical treatment is often required.

摘要

目的

报告一例由 引起的坏死性巩膜炎的治疗和结果。

方法

病例报告。

结果

一名 79 岁女性左眼意外被金雀花刺伤后出现巩膜炎症。损伤部位形成脓肿,行脓肿切开引流术。从脓肿内容物中分离出丝状真菌,并给予口服伏立康唑和局部伏立康唑及那他霉素滴眼剂治疗。表型分析证实存在 ,对伏立康唑和两性霉素 B 的最低抑菌浓度(MIC)较低。两周后,患者出现坏死性巩膜炎,需要行手术清创和巩膜移植。3 个月后,巩膜炎症消退,遗留一处巩膜软化。

结论

是一种常见的环境真菌,最近已成为人类病原体和罕见的巩膜炎病因。据我们所知,这是首例从纯培养物中获得 的巩膜炎报告。由于抗真菌药敏性的报道有限,成功的治疗极具挑战性,通常需要联合药物和手术治疗。

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