癌胚抗原相关细胞黏附分子5（CEACAM5）是一种白细胞介素-13调节的上皮基因，它在2型（T2）重度哮喘中介导转录。 - Suppr

CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

作者信息

Mumby Sharon, Kermani Nazanin Zounemat, Garnett James P, Pavlidis Stelios, Wilson Susan J, Howarth Peter J, Thomas Matthew J, Adcock Ian M, López-García Carlos

机构信息

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.

Department of Computing, Data Science Institute, Imperial College London, London, UK.

出版信息

Allergy. 2022 Nov;77(11):3463-3466. doi: 10.1111/all.15465. Epub 2022 Aug 12.

DOI:10.1111/all.15465

PMID:35916059

Abstract

摘要

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CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

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引用本文的文献

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CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

作者信息

Mumby Sharon, Kermani Nazanin Zounemat, Garnett James P, Pavlidis Stelios, Wilson Susan J, Howarth Peter J, Thomas Matthew J, Adcock Ian M, López-García Carlos

机构信息

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.

Department of Computing, Data Science Institute, Imperial College London, London, UK.

出版信息

Allergy. 2022 Nov;77(11):3463-3466. doi: 10.1111/all.15465. Epub 2022 Aug 12.

DOI:10.1111/all.15465

PMID:35916059

Abstract

摘要

相似文献

CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

Allergy. 2022 Nov;77(11):3463-3466. doi: 10.1111/all.15465. Epub 2022 Aug 12.

Elevated CEACAM5 Levels in Patients with Asthma.

Int Arch Allergy Immunol. 2022;183(6):673-681. doi: 10.1159/000521754. Epub 2022 Feb 16.

Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.

BMC Cancer. 2015 Dec 16;15:975. doi: 10.1186/s12885-015-1950-1.

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus.

J Virol. 2016 Sep 29;90(20):9114-27. doi: 10.1128/JVI.01133-16. Print 2016 Oct 15.

Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer.

Clin Cancer Res. 2021 Feb 1;27(3):759-774. doi: 10.1158/1078-0432.CCR-20-3396. Epub 2020 Nov 16.

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity.

Cancer Immunol Immunother. 2017 Nov;66(11):1425-1436. doi: 10.1007/s00262-017-2034-7. Epub 2017 Jun 28.

CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2.

Clin Sci (Lond). 2022 Nov 30;136(22):1691-1710. doi: 10.1042/CS20220581.

Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors.

Clin Cancer Res. 2020 Dec 15;26(24):6589-6599. doi: 10.1158/1078-0432.CCR-19-4051. Epub 2020 Oct 12.

A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo.

Cancer Lett. 2022 Jan 28;525:97-107. doi: 10.1016/j.canlet.2021.10.041. Epub 2021 Nov 3.

KRT19 and CEACAM5 mRNA-marked circulated tumor cells indicate unfavorable prognosis of breast cancer patients.

Breast Cancer Res Treat. 2019 Apr;174(2):375-385. doi: 10.1007/s10549-018-05069-9. Epub 2018 Dec 8.

引用本文的文献

Machine learning-based screening of asthma biomarkers and related immune infiltration.

Front Allergy. 2025 Jan 29;6:1506608. doi: 10.3389/falgy.2025.1506608. eCollection 2025.

Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations.

Nat Commun. 2024 May 28;15(1):4546. doi: 10.1038/s41467-024-48507-7.

The effects of inhaled corticosteroids on healthy airways.

Allergy. 2024 Jul;79(7):1831-1843. doi: 10.1111/all.16146. Epub 2024 Apr 30.

Chronic alcohol use primes bronchial cells for altered inflammatory response and barrier dysfunction during SARS-CoV-2 infection.

Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L647-L661. doi: 10.1152/ajplung.00381.2022. Epub 2023 Oct 3.

CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

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CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma.

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