Karlsruhe Institute of Technology (KIT), Institute for Inorganic Chemistry, Engesserstrasse 15, 76131, Karlsruhe, Germany.
University Medical Center Goettingen (UMG), Institute for Diagnostic and Interventional Radiology, Robert Koch Str. 40, 37075, Goettingen, Germany.
Chem Commun (Camb). 2022 Aug 18;58(67):9417-9420. doi: 10.1039/d2cc01507b.
Saline inorganic-organic hybrid nanoparticles (IOH-NPs) [La(OH)][ARS] (ARS: alizarin red S) are prepared in water as a new compound (particle size: 47 ± 7 nm, ARS load: 65 wt%). The IOH-NPs not only show a pH-dependent absorption colour but also a pH-dependent fluorescence with green emission at pH 5.0-9.0 and red emission at pH < 4.5. According to first studies, the pH-dependend fluorescence can be used to monitor nanoparticle internalization in cells as well as the respective intracellular pH.
盐水无机-有机杂化纳米粒子（IOH-NPs）[La(OH)][ARS]（ARS：茜素红 S）在水中制备为一种新化合物（粒径：47 ± 7nm，ARS 负载：65wt%）。IOH-NPs 不仅显示出 pH 值依赖性的吸收颜色，而且在 pH 值为 5.0-9.0 时显示出 pH 值依赖性的荧光，发出绿色发射，在 pH < 4.5 时发出红色发射。根据初步研究，pH 值依赖性荧光可用于监测细胞内纳米颗粒的内化以及相应的细胞内 pH 值。
