感染艾滋病毒女性的宫颈和肛门同时感染高危型人乳头瘤病毒：一项观察性病例对照研究。

Concurrent Cervical and Anal High-Risk Human Papillomavirus Infection in Women Living With HIV: An Observational Case-Control Study.

作者信息

Gupta Ruchika, Hussain Showket, Hariprasad Roopa, Dhanasekaran Kavitha, Verma Sheel, Agarwal Vineeta, Das Pradeep K, Singh Sompal, Gupta Sanjay

机构信息

Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

出版信息

J Acquir Immune Defic Syndr. 2022 Nov 1;91(3):319-324. doi: 10.1097/QAI.0000000000003064.

DOI:10.1097/QAI.0000000000003064

PMID:35916635

Abstract

BACKGROUND

To evaluate the prevalence and correlates of concurrent uterine cervical and anal HR-HPV infections in women living with HIV (WLHIV).

SETTING

A cross-sectional study was undertaken at a tertiary care hospital and linked ART center.

METHODS

One hundred and forty-one WLHIV and 161 HIV-negative women were enrolled for cervical and anal cytology as well as HR-HPV testing using the HC2 method. Screen-positive women were followed-up with colposcopy/anoscopy and/or repeat cytology. Appropriate statistical tests were applied to assess the association of concurrent HR-HPV with various parameters.

RESULTS

Concurrent cervical and anal HR-HPV infection was detected in 22 WLHIV (16.3%) and 5 HIV-negative women (3.1%), the difference being statistically significant ( P < 0.001 ). Among WLHIV, concurrent HR-HPV was associated with tobacco use ( P < 0.001 ), receptive anal intercourse ( P = 0.02 ), low CD4 counts ( P = 0.001 ), and negatively with ART intake ( P = 0.004 ) on bivariate analysis. Multivariate logistic regression analysis showed a positive association of concurrent HR-HPV positivity with tobacco use ( P = 0.02 ) and low nadir CD4 counts ( P = 0.03 ).

CONCLUSIONS

WLHIV, especially those with CD4 counts less than 200/µL, should be offered HR-HPV screening and follow-up to detect cervical and anal lesions.

摘要

背景

评估感染艾滋病毒女性（WLHIV）中子宫颈和肛门高危型人乳头瘤病毒（HR-HPV）合并感染的患病率及其相关因素。

设置

在一家三级护理医院及附属抗逆转录病毒治疗中心进行了一项横断面研究。

方法

招募了141名感染艾滋病毒女性和161名未感染艾滋病毒女性，进行子宫颈和肛门细胞学检查以及采用HC2方法进行HR-HPV检测。筛查呈阳性的女性接受阴道镜/肛门镜检查和/或重复细胞学检查。应用适当的统计学检验评估HR-HPV合并感染与各种参数之间的关联。

结果

在22名感染艾滋病毒女性（16.3%）和5名未感染艾滋病毒女性（3.1%）中检测到子宫颈和肛门HR-HPV合并感染，差异具有统计学意义（P<0.001）。在感染艾滋病毒女性中，双变量分析显示，HR-HPV合并感染与吸烟（P<0.001）、接受肛交（P=0.02）、低CD4细胞计数（P=0.001）相关，与接受抗逆转录病毒治疗呈负相关（P=0.004）。多变量逻辑回归分析显示，HR-HPV合并感染阳性与吸烟（P=0.02）和低最低点CD4细胞计数（P=0.03）呈正相关。