Multidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, 58 Rio de Contas Street - 17 Block - 58 Lot|Candeias, 45.029-094 Vitória da Conquista, Bahia, Brazil.
Multidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, 58 Rio de Contas Street - 17 Block - 58 Lot|Candeias, 45.029-094 Vitória da Conquista, Bahia, Brazil; Paulo Freire Campus - Federal University of Southern Bahia, 250 Joana Angélica Square|São José, 45.988-058 Teixeira de Freitas, Bahia, Brazil.
Exp Gerontol. 2022 Oct 1;167:111905. doi: 10.1016/j.exger.2022.111905. Epub 2022 Jul 30.
Due to the inflammatory nature of type 2 diabetes mellitus (T2DM) and the increased cardiovascular risk, there is a growing need for innovative strategies to change our identification and treatment approach to avoid clinical complications. One approach would be the use of circulating biomarkers to track disease progression and management. Thus, this study aimed to evaluate the concentrations of inflammatory biomarkers in patients diagnosed with type 2 diabetes mellitus and systemic arterial hypertension, correlating inflammatory cytokines and disease severity. Initially, 259 individuals were stratified into different degrees of disease: low risk, moderate risk, high risk, and very high risk, according to the European Society of Cardiology, which correlates blood pressure values with the presence of cardiovascular risk factors. For this stratification, analysis of body composition, blood pressure measurement, and questionnaires were applied. Blood was collected for biochemical measurements and for ELISA to detect concentrations of cytokines IL-17, IL-1β, IFN-Y, TNF-α, and IL-10. The findings suggest that inflammation is present, contributing to the worsening of systemic arterial hypertension and type 2 diabetes mellitus. Through Bayesian analysis, we found that hyperglycemia plays a role in fueling inflammation, contributing to the maintenance of the state of dysregulation and persistent inflammation, which can contribute to systemic damage. Our work correlates biochemical, glycemic, body composition, blood pressure and inflammatory profiles, showing how they participate together in worsening the prognosis of patients diagnosed with chronic non-communicable diseases. We have seen that all these parameters can be changed with the practice of physical activity, even in conditions of obesity, hyperglycemia or dyslipidemia, when patients do not control the changes with standard pharmacological treatment. Thus, the management measures of these chronic non-communicable diseases must take into account the crosstalk between the systems, and the dysregulation of just one of these systems is enough to generate consequences in all the other systems.
由于 2 型糖尿病（T2DM）的炎症性质和心血管风险增加，因此需要创新策略来改变我们的识别和治疗方法，以避免临床并发症。一种方法是使用循环生物标志物来跟踪疾病进展和管理。因此，本研究旨在评估患有 2 型糖尿病和系统性动脉高血压的患者的炎症生物标志物浓度，将炎症细胞因子与疾病严重程度相关联。最初，根据欧洲心脏病学会（ESC）将血压值与心血管危险因素相关联，将 259 名个体分为不同程度的疾病：低风险、中风险、高风险和极高风险。为了进行这种分层，应用了身体成分分析、血压测量和问卷调查。采集血液进行生化测量和 ELISA 检测以检测细胞因子 IL-17、IL-1β、IFN-Y、TNF-α 和 IL-10 的浓度。研究结果表明炎症存在，导致系统性动脉高血压和 2 型糖尿病的恶化。通过贝叶斯分析，我们发现高血糖在引发炎症中起作用，有助于维持失调和持续炎症的状态，这可能导致全身性损伤。我们的工作将生化、血糖、身体成分、血压和炎症谱相关联，显示它们如何共同参与恶化慢性非传染性疾病患者的预后。我们已经看到，所有这些参数都可以通过进行体育活动来改变，即使在肥胖、高血糖或血脂异常的情况下，当患者不能通过标准药物治疗来控制这些变化时也是如此。因此，这些慢性非传染性疾病的管理措施必须考虑到系统之间的相互作用，仅仅一个系统的失调就足以在所有其他系统中产生后果。
