Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, China.
State Key Laboratory of Membrane Biology, School of Medicine, Institute of Precision Medicine, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.
FEBS Lett. 2022 Oct;596(20):2668-2677. doi: 10.1002/1873-3468.14460. Epub 2022 Aug 16.
Exosomes released by mesenchymal stem cells (MSCs) are thought to function as extensions of the MSCs. However, it remains unclear whether exosomes derived from human umbilical cord MSCs (HUMSCs) possess immunoregulatory functions in rheumatoid arthritis. We report that when mice with collagen-induced arthritis were injected with exosomes derived from HUMSC (HUMSC-Exo), their paws became less swollen, and they had lower serum pro-inflammatory cytokine and anti-collagen IgG levels, and decreased synovial hyperplasia. The HUMSC-Exo appeared to restore the balance between Th17 and Treg cells, and this effect was accompanied by reduced IL-17 and enhanced TGF-β and IL-10 levels. These findings suggest that HUMSC-Exo function as important regulator of the balance between Th1/Th17 and Treg cells during immune and inflammatory responses.
间充质干细胞（MSCs）释放的外泌体被认为是 MSC 的延伸。然而，目前尚不清楚源自人脐带间充质干细胞（HUMSC）的外泌体是否在类风湿关节炎中具有免疫调节功能。我们报告称，当胶原诱导性关节炎的小鼠注射 HUMSC 衍生的外泌体（HUMSC-Exo）时，它们的爪子肿胀程度减轻，血清促炎细胞因子和抗胶原 IgG 水平降低，滑膜增生减少。HUMSC-Exo 似乎恢复了 Th17 和 Treg 细胞之间的平衡，这种作用伴随着 IL-17 的减少和 TGF-β 和 IL-10 的增加。这些发现表明，HUMSC-Exo 作为免疫和炎症反应过程中 Th1/Th17 和 Treg 细胞之间平衡的重要调节剂发挥作用。
