Wu Jinhui, Wu Jiangyi, Liu Zheng, Gong Yunquan, Feng Daibo, Xiang Wei, Fang Shunzheng, Chen Ran, Wu Yaran, Huang Shu, Zhou Yizhao, Liu Ningning, Xu Hao, Zhou Siru, Liu Baorong, Ni Zhenhong
Department of Joint Surgery and Sport Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410000, China.
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, China.
J Orthop Translat. 2024 Jul 27;48:53-69. doi: 10.1016/j.jot.2024.07.005. eCollection 2024 Sep.
Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint diseases have several limitations, such as unsatisfatory efficacy and side effects, necessitating the exploration of more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have demonstrated high therapeutic efficacyin tissue repair and regeneration, with low immunogenicity and tumorigenicity. Recent studies have reported that EVs-based therapy has considerable therapeutic effects against joint diseases, including osteoarthritis, tendon and ligament injuries, femoral head osteonecrosis, and rheumatoid arthritis. Herein, we review the therapeutic potential of various types of MSC-EVs in the aforementioned joint diseases, summarise the mechanisms underlying specific biological effects of MSC-EVs, and discuss future prospects for basic research on MSC-EV-based therapeutic modalities and their clinical translation. In general, this review provides an in-depth understanding of the therapeutic effects of MSC-EVs in joint diseases, as well as the underlying mechanisms, which may be beneficial to the clinical translation of MSC-EV-based treatment. The translational potential of this article: MSC-EV-based cell-free therapy can effectively promote regeneration and tissue repair. When used to treat joint diseases, MSC-EVs have demonstrated desirable therapeutic effects in preclinical research. This review may supplement further research on MSC-EV-based treatment of joint diseases and its clinical translation.
关节疾病对全球患者的日常生活和职业功能有极大影响。然而，关节疾病的传统治疗存在一些局限性，如疗效不尽人意和有副作用，因此需要探索更有效的治疗策略。间充质干细胞（MSC）衍生的细胞外囊泡（MSC-EV）已在组织修复和再生中显示出高治疗效果，且免疫原性和致瘤性低。最近的研究报告称，基于细胞外囊泡的疗法对包括骨关节炎、肌腱和韧带损伤、股骨头坏死以及类风湿性关节炎在内的关节疾病具有显著治疗效果。在此，我们综述了各类MSC-EV在上述关节疾病中的治疗潜力，总结了MSC-EV特定生物学效应的潜在机制，并讨论了基于MSC-EV的治疗方式基础研究及其临床转化的未来前景。总体而言，本综述深入阐述了MSC-EV在关节疾病中的治疗效果及其潜在机制，这可能有助于基于MSC-EV的治疗的临床转化。本文的转化潜力：基于MSC-EV的无细胞疗法可有效促进再生和组织修复。在用于治疗关节疾病时，MSC-EV在临床前研究中已显示出理想的治疗效果。本综述可能为基于MSC-EV治疗关节疾病及其临床转化的进一步研究提供补充。
