干扰素受体 1、脑源性神经营养因子和白细胞介素 10 的遗传变异可能预测中国乳腺癌女性抑郁和焦虑的易感性。

Genetic Variations in IFNGR1, BDNF and IL-10 May Predict the Susceptibility to Depression and Anxiety in Chinese Women With Breast Cancer.

机构信息

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Department of Medical Oncology, Cancer Hospital of Huanxing Chaoyang District, Beijing 100122, China.

出版信息

Clin Breast Cancer. 2022 Oct;22(7):674-680. doi: 10.1016/j.clbc.2022.07.002. Epub 2022 Jul 9.

DOI:10.1016/j.clbc.2022.07.002

PMID:35918221

Abstract

BACKGROUND

A large number of breast cancer survivors suffer from psychological distress. The purpose of this study was to investigate the association between genetic variations in Chinese breast cancer patients and anxiety or depression, and to screen patients who are susceptible to psychological problems.

METHODS

A total of 300 early-stage breast cancer patients were recruited in this prospective observational single-center cohort study. With reference to the previous literature and the mechanism concerning anxiety and depression, 9 candidate genes and 29 single-nucleotide polymorphisms (SNPs) loci were selected. The association between SNP variations and anxiety/depression were analyzed.

RESULTS

After we incorporated meaningful clinicopathological and demographic factors, multivariate analysis showed that the A/G and G/G genotypes of IFNGR1 (rs2234711) and the T/C and T/T genotypes of BDNF (rs6265) were significantly associated with depression (HR 3.10, P = .008; HR 2.04, P = .03). The G/A and G/G genotypes of IL-10 (rs1554286) remained independent predictors of anxiety (HR 1.85, P = .019).

CONCLUSIONS

These findings suggested that variations in IL-10, IFNGR1 and BDNF were associated with anxious/depressive symptoms in early-stage breast cancer patients in China, which could help identify patients at high risk for psychological problems.

摘要

背景

大量乳腺癌幸存者患有心理困扰。本研究旨在探讨中国乳腺癌患者基因变异与焦虑或抑郁的关系，并筛选易出现心理问题的患者。

方法

本前瞻性观察性单中心队列研究共招募了 300 例早期乳腺癌患者。参考先前的文献和焦虑抑郁的相关机制，选择了 9 个候选基因和 29 个单核苷酸多态性（SNP）位点。分析 SNP 变异与焦虑/抑郁的关系。

结果

在纳入有意义的临床病理和人口统计学因素后，多变量分析显示 IFNGR1(rs2234711)的 A/G 和 G/G 基因型和 BDNF(rs6265)的 T/C 和 T/T 基因型与抑郁显著相关（HR 3.10，P=0.008；HR 2.04，P=0.03）。IL-10(rs1554286)的 G/A 和 G/G 基因型仍然是焦虑的独立预测因子（HR 1.85，P=0.019）。