抗脂阿拉伯甘露聚糖/阿拉伯甘露聚糖单克隆抗体 - 结核分枝杆菌研究和诊断的特性及意义。
Monoclonal antibodies to lipoarabinomannan/arabinomannan - characteristics and implications for tuberculosis research and diagnostics.
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
Trends Microbiol. 2023 Jan;31(1):22-35. doi: 10.1016/j.tim.2022.07.001. Epub 2022 Jul 30.
Abstract
Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.
摘要
针对分枝杆菌表面糖脂脂阿拉伯甘露聚糖 (LAM) 及其相关荚膜多糖阿拉伯甘露聚糖 (AM) 的抗体，对于研究理解针对结核分枝杆菌 (Mtb) 的保护机制以及开发下一代即时结核病 (TB) 诊断方法，变得越来越重要。本文概述了针对 LAM/AM 的单克隆抗体 (mAb) 的不断发展的研究管线。本文回顾了它们的生成的新旧方法，并概述和讨论了它们的聚糖表位特异性和其他特征，这些特征对 TB 领域具有重要意义。
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