Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Gene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Lasers Med Sci. 2022 Dec;37(9):3321-3331. doi: 10.1007/s10103-022-03621-0. Epub 2022 Aug 3.
Scarring is one of the most esthetically challenging and psychologically burdening aspects following inflammatory acne. While "macular" disease is the scar subtype with the least complicated outcome, its phase can be regarded as the most defining in the ultimate scar appearance. Moreover, with lasers recently gaining much popularity in the scientific community for managing several dermatologic conditions, we aimed to evaluate whether they would lead to significant benefits. For this systematic review, four databases consisting of PubMed, Scopus, Embase, and Web of Science were searched using a comprehensive string, with the data from the relevant yet eligible identified records qualitatively synthesized. After investigating the data obtained from the nine included studies, we found the utilized lasers, namely neodymium-doped yttrium aluminum garnet, fractional carbon dioxide, pulsed dye, erbium:glass, pro-yellow, and high-power optically pumped semiconductor, to be highly effective in managing the erythematous or dyspigmented appearance with the reduced elasticity also significantly improving. Moreover, the adverse events were both bearable and minimal, and transient. However, the degree of improvement each type of scar demonstrated following laser therapy varied based on the laser used. Neodymium-doped yttrium aluminum garnet, fractional carbon dioxide, and pulsed dye are the most commonly investigated lasers for managing macular acne scars, demonstrating eye-catching capabilities in managing either erythema or dyspigmentation. However, we still recommend that further comparative interventional studies be carried out, while the intended outcomes also assessed with objective measures for further clarification.
瘢痕是炎症性痤疮后最具美学挑战性和心理负担的方面之一。虽然“斑片状”疾病是瘢痕亚型中结局最不复杂的，但它的阶段可以被认为是最终瘢痕外观中最具决定性的。此外，由于激光在科学界最近因管理多种皮肤病而广受欢迎，我们旨在评估它们是否会带来显著的益处。在这项系统评价中，我们使用综合字符串搜索了包含 PubMed、Scopus、Embase 和 Web of Science 的四个数据库，并对相关但符合条件的记录进行了定性综合。在调查了 9 项纳入研究的数据后，我们发现所使用的激光，即掺钕钇铝石榴石、分束二氧化碳、脉冲染料、铒玻璃、脯氨酸黄和高功率光泵半导体，在管理红斑或色素减退外观方面非常有效，同时还显著改善了弹性降低的问题。此外，不良反应是可耐受的且轻微的，是暂时的。然而，每种类型的瘢痕在激光治疗后改善的程度因使用的激光而异。掺钕钇铝石榴石、分束二氧化碳和脉冲染料是治疗斑片状痤疮瘢痕最常用的激光，在治疗红斑或色素减退方面表现出了引人注目的能力。然而，我们仍建议进行进一步的比较干预研究，并使用客观措施评估预期的结果，以进一步澄清。
